gene 1,544 words KG: VPS4A
Contents

VPS4A — Vacuolar Protein Sorting 4 Homolog A

🧬 Gene Info
Gene SymbolVPS4A
Full NameVacuolar Protein Sorting 4 Homolog A
Chromosome16q22.1
Functionencodes an AAA+ ATPase involved in endosomal sorting, multivesicular body formation, and autophagy.
Molecular Weight48 kDa
Amino Acids437 aa
PathwaysAutophagosome-lysosome Fusion, Autophagy, autophagy pathway
UniProt IDQ9Y5X0
NCBI Gene ID27183
Ensembl IDENSG00000167842
OMIM609434
GeneCardsVPS4A
Human Protein AtlasVPS4A
Associated Diseasesneurodegeneration
Known Drugs/CompoundsAloperine
InteractionsActin, AMPK, AND, APOPTOSIS, AUTOPHAGY, CANCER
KG Connections79 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (9)

Lysosomal Membrane Repair Enhancement
Score: 0.54
Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
Cross-Seeding Prevention Strategy
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67
Glycine-Rich Domain Competitive Inhibition
Score: 0.64

Related Analyses (7)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (15)

Neurodegeneration
disease · KG edge: regulates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: inhibits
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibits
ATG14 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SQSTM1 inhibits VPS4A
CHMP1B activates VPS4A
JUN activates VPS4A
VPS4A inhibits SQSTM1
TFEB associated_with VPS4A
NBR1 associated_with VPS4A
FOXO1 associated_with VPS4A
PPARA associated_with VPS4A
SQSTM1 associated_with VPS4A
OPTN associated_with VPS4A

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