protein

VPS4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VPS4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

34Connections

0Hypotheses

0Analyses

15Outgoing

19Incoming

0Experiments

0Debates

Summary

Page for VPS4 Protein

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🔬 Protein Info

Gene Symbol	VPS4
Function	VPS4 (Vacuolar Protein Sorting 4 Homolog) is an AAA+ ATPase that functions in the final stages of multivesicular body (MVB) sorting and autophagy
Primary Expression	neuronal tissues
Amino Acids	437 aa
UniProt ID	VPS4A
GeneCards	VPS4
Human Protein Atlas	VPS4
AAA+ ATPase domain	Hexameric ring that hydrolyzes ATP for disassembly
C-terminal region	Contains autoinhibitory domain
VPS4A	Ubiquitously expressed isoform
VPS4B	Predominantly expressed in neuronal tissues
ESCRT-III disassembly	Uses ATP hydrolysis to disassemble ESCRT-III polymers
MVB sorting	Essential for sorting ubiquitinated cargo into intralumenal vesicles
Autophagosome closure	Involved in autophagosome closure and lysosomal fusion
Cytokinetic abscission	Required for membrane fission during cytokinesis
Associated Diseases	neurodegeneration
Interactions	ALS, AND, App, APP, CHMP2B, CHMP4B
KG Connections	34 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    N0["VPS4"]
    N1["Als"]
    N0 -->|"activates"| N1
    N2["ALS"]
    N0 -->|"activates"| N2
    N3["CHMP2B"]
    N0 -->|"interacts with"| N3
    N4["CHMP4B"]
    N0 -->|"interacts with"| N4
    N5["Neuron"]
    N0 -->|"activates"| N5
    N6["CHMP7"]
    N0 -->|"interacts with"| N6
    N7["Ras"]
    N0 -->|"activates"| N7
    N8["App"]
    N0 -->|"interacts with"| N8
    N4 -->|"interacts with"| N0
    N3 -->|"interacts with"| N0
    N9["AND"]
    N9 -->|"interacts with"| N0
    N6 -->|"interacts with"| N0
    N0 -->|"expressed in"| N5
    N10["Proteins"]
    N0 -->|"interacts with"| N10

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 gene
    class N3 gene
    class N4 gene
    class N6 gene
    class N7 protein
    class N8 protein
    class N9 gene
    class N10 protein

Outgoing (15)

Target	Relation	Type	Str
Als	activates	disease	0.65
Neuron	activates	cell_type	0.60
CHMP2B	interacts_with	gene	0.60
CHMP4B	interacts_with	gene	0.60
ALS	activates	gene	0.60
neurons	expressed_in	cell_type	0.60
autophagy pathway	participates_in	pathway	0.60
CHMP7	interacts_with	gene	0.60
Ras	activates	protein	0.60
App	interacts_with	protein	0.60
Neuron	expressed_in	cell_type	0.55
VPS4A	interacts_with	gene	0.55
VPS4A	inhibits	gene	0.55
Alzheimer's disease	inhibits	disease	0.55
Proteins	interacts_with	protein	0.50

Incoming (19)

Source	Relation	Type	Str
AND	interacts_with	gene	0.60
APP	activates	gene	0.60
CHMP6	activates	gene	0.60
CHMP7	expressed_in	gene	0.60
CHMP7	associated_with	gene	0.60
ALS	expressed_in	gene	0.60
CHMP4B	interacts_with	gene	0.60
CHMP2B	interacts_with	gene	0.60
CHMP7	interacts_with	gene	0.60
ESCRT-III	interacts_with	gene	0.55
ATP	regulates	gene	0.55
CHMP2B	associated_with	gene	0.55
CHMP4B	targets	gene	0.55
CHMP4B	activates	gene	0.50
CHMP2B	activates	gene	0.50
CHMP7	activates	gene	0.50
CHMP7	inhibits	gene	0.50
GSDMD	co_expressed_with	protein	0.50
MLKL	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VPS4 in their description or question text

No additional research found