gene 1,363 words KG: TBP
Contents

TBP - TATA-Box Binding Protein

🧬 Gene Info
Gene SymbolTBP
Full NameTATA-Box Binding Protein
Chromosome6q27
Protein TypeTranscription Factor
Functionis a general transcription factor essential for RNA polymerase II-mediated transcription initiation.
Amino Acids339 aa
Exons8
PathwaysAmyloid
UniProt IDP20226
NCBI Gene ID6908
Ensembl IDENSG00000112592
OMIM600075
GeneCardsTBP
Human Protein AtlasTBP
Associated Diseasesneurodegeneration
InteractionsAND, AXIN1, CCND1, EGR1, GENES, HNF4A
KG Connections57 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (3)

TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (13)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: regulates
Genes
index · KG edge: activates
AXIN1 Gene
gene · KG edge: activates
EGR1 Gene
gene · KG edge: activates
HNF4A - Hepatocyte Nuclear Factor 4 Alpha
gene · KG edge: activates

Knowledge Graph (12 edges)

HSP70 expressed_in TBP
TXNIP activates TBP
SOCS3 activates TBP
YWHAZ activates TBP
MYC activates TBP
STAT3 activates TBP
EGR1 activates TBP
TBP activates RELA
TBP activates RHEB
TBP activates SPI1

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