gene 3,381 words KG: PTBP2
Contents

PTBP2 - Polypyrimidine Tract Binding Protein 2

🧬 Gene Info
Gene SymbolPTBP2
Full NamePolypyrimidine Tract Binding Protein 2
Chromosome5q31.2
Protein FamilyPTB family (RNA binding proteins)
FunctionRNA recognition motifs (RRMs): Four RRMs (RRM1-4) bind to polypyrimidine tracts in target pre-mRNAs
Primary ExpressionUbiquitous
UniProt IDQ9UKJ3
NCBI Gene ID58160
Ensembl IDENSG00000117569
GeneCardsPTBP2
Human Protein AtlasPTBP2
Associated DiseasesAlzheimer's disease, Parkinson's disease, ALS
DatabasesGeneCardsHPASTRING

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Related Hypotheses (8)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (7)

RNA binding protein dysregulation across ALS FTD AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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