gene

SYNAPTOPHYSIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNAPTOPHYSIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

316Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SYNAPTOPHYSIN is a gene implicated in neurodegeneration research. Key relationships include: activates, treats, biomarker for. Associated with ALS, Aging, Als. Connected to 153 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SYP
Full Name	Synaptophysin
Chromosome	Xp11.23
Function	Synaptophysin is the most abundant synaptic vesicle membrane protein, constituting up to 10% of all synaptic vesicle proteins.
Primary Expression	Brain (cortex, hippocampus), cerebellum, retina, neuroendocrine cells
Molecular Weight	38 kDa
Amino Acids	316 aa
Pathways	Amyloid, Apoptosis
UniProt ID	P21579
Ensembl ID	ENSG00000100391
GeneCards	SYP
Human Protein Atlas	SYP
Associated Diseases	ALS, Epilepsy, Ms
Interactions	AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, ANXIETY
KG Connections	315 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SYNAPTOPHYSIN — AlphaFold P21579 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

synaptophysin

gene · 2227 words

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Pathway Diagram

flowchart TD
    ATG9A["ATG9A"] -->|"co-localizes"| SYNAPTOPHYSIN["SYNAPTOPHYSIN"]
    SYNAPTOPHYSIN["SYNAPTOPHYSIN"] -->|"biomarker for"| Inflammation["Inflammation"]
    SYNAPTOPHYSIN["SYNAPTOPHYSIN"] -->|"biomarker for"| Als["Als"]
    SYNAPTOPHYSIN["SYNAPTOPHYSIN"] -->|"biomarker for"| Neuroinflammation["Neuroinflammation"]
    SYNAPTOPHYSIN["SYNAPTOPHYSIN"] -->|"biomarker for"| Aging["Aging"]
    SYNAPTOPHYSIN["SYNAPTOPHYSIN"] -->|"biomarker for"| Alzheimer["Alzheimer"]
    SYNAPTOPHYSIN["SYNAPTOPHYSIN"] -->|"biomarker for"| Ms["Ms"]
    SYNAPTOPHYSIN["SYNAPTOPHYSIN"] -->|"activates"| Alzheimer["Alzheimer"]
    SYNAPTOPHYSIN["SYNAPTOPHYSIN"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
    SYNAPTOPHYSIN["SYNAPTOPHYSIN"] -->|"activates"| Inflammation["Inflammation"]
    SYNAPTOPHYSIN["SYNAPTOPHYSIN"] -->|"activates"| Tumor["Tumor"]
    SYNAPTOPHYSIN["SYNAPTOPHYSIN"] -->|"activates"| Ms["Ms"]
    style ATG9A fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style SYNAPTOPHYSIN fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neuroinflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (234)

Target	Relation	Type	Str
Tumor	activates	disease	0.75
Inflammation	activates	disease	0.75
Neuroinflammation	activates	disease	0.75
Alzheimer	activates	disease	0.75
Neurodegeneration	treats	disease	0.75
Als	treats	disease	0.75
NEURODEGENERATION	treats	gene	0.70
SYNAPSE	inhibits	gene	0.70
TNF-Α	activates	gene	0.70
BDNF	activates	gene	0.70
Synaptic Plasticity	activates	pathway	0.70
GFAP	activates	gene	0.70
PSD95	activates	gene	0.70
TNF	activates	gene	0.70
Traumatic Brain Injury	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
ALS	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Epilepsy	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Ms	activates	disease	0.65
Anxiety	interacts_with	disease	0.65
Neuroinflammation	treats	disease	0.65
Inflammation	treats	disease	0.65
Alzheimer	expressed_in	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Parkinson	activates	disease	0.65
Diabetes	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Inflammation	protects_against	disease	0.65
ALS	biomarker_for	disease	0.65
Aging	treats	disease	0.65
Inflammation	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Aging	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Ms	expressed_in	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Stroke	activates	disease	0.65
Depression	activates	disease	0.65
Tumor	biomarker_for	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Traumatic Brain Injury	treats	disease	0.65
Inflammation	therapeutic_target	disease	0.65

Incoming (82)

Source	Relation	Type	Str
ATG9A	co-localizes	gene	0.90
NPFF	upregulates	protein	0.90
CCL5	upregulates	protein	0.88
SLC17A7	co-expressed_with	gene	0.85
DHT	regulates	compound	0.80
TNF	activates	gene	0.60
APP	activates	gene	0.60
TAU	activates	gene	0.60
APP	regulates	gene	0.60
MAPT	regulates	gene	0.60
SLC17A7	activates	gene	0.60
BACE1	regulates	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
BACE1	biomarker_for	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60
AMYLOID	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
BAX	treats	gene	0.60
P38	activates	gene	0.60
TNF	expressed_in	gene	0.60
PSD95	inhibits	gene	0.60
CCR5	activates	gene	0.60
ERK1/2	activates	gene	0.60
CHAT	associated_with	gene	0.60
ALZHEIMER	inhibits	gene	0.60
EPILEPSY	associated_with	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
HDAC	activates	gene	0.60
TAU	biomarker_for	gene	0.60
AMYLOID	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
NEUROINFLAMMATION	biomarker_for	gene	0.60
AND	biomarker_for	gene	0.60
SYNAPSE	inhibits	gene	0.60
NEURODEGENERATION	activates	gene	0.60
FGF	activates	gene	0.60
BRAIN INJURY	activates	gene	0.60
AXON	inhibits	gene	0.60
AND	inhibits	gene	0.60
NEURON	activates	gene	0.60
SV2A	associated_with	gene	0.60
GAP43	associated_with	gene	0.60
PSD95	associated_with	gene	0.60
TNF	biomarker_for	gene	0.60
BDNF	biomarker_for	gene	0.60
GFAP	biomarker_for	gene	0.60
TRKB	biomarker_for	gene	0.60
SYP	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SYNAPTOPHYSIN in their description or question text

No additional research found