gene 2,227 words KG: SYNAPTOPHYSIN
Contents

SYNAPTOPHYSIN Gene

🧬 Gene Info
Gene SymbolSYP
Full NameSynaptophysin
ChromosomeXp11.23
FunctionSynaptophysin is the most abundant synaptic vesicle membrane protein, constituting up to 10% of all synaptic vesicle proteins.
Primary ExpressionBrain (cortex, hippocampus), cerebellum, retina, neuroendocrine cells
Molecular Weight38 kDa
Amino Acids316 aa
PathwaysAmyloid, Apoptosis
UniProt IDP21579
Ensembl IDENSG00000100391
GeneCardsSYP
Human Protein AtlasSYP
Associated DiseasesALS, Epilepsy, Ms
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, ANXIETY, APP
KG Connections309 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (53)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Phase-Separated Organelle Targeting
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Purinergic Signaling Polarization Control
Score: 0.71
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Orexin-Microglia Modulation Therapy
Score: 0.71
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
SASP-Mediated Complement Cascade Amplification
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
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Related Analyses (23)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (12)

DLB Cognitive Fluctuation Mechanism Experiment
clinical · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
Blood-Brain Barrier Aging and Neurodegeneration — From Leaka
validation · proposed · Score: 0.40

See Also (5)

blarcamesine-axon
clinical_trial · KG edge: inhibits
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: biomarker_for
ATG9A Gene
gene · KG edge: co-localizes
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

SYNAPTOPHYSIN biomarker_for BACE1
SYNAPTOPHYSIN biomarker_for NFL
BACE1 biomarker_for SYNAPTOPHYSIN
TNF activates SYNAPTOPHYSIN
APP activates SYNAPTOPHYSIN
SYNAPTOPHYSIN activates IL6
SYNAPTOPHYSIN activates BDNF
SYNAPTOPHYSIN activates GFAP
NFL biomarker_for SYNAPTOPHYSIN
ATG9A co-localizes SYNAPTOPHYSIN

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