| Gene Symbol | SREBF1 (SREBP1) |
| Full Name | Sterol Regulatory Element Binding Transcription Factor 1 |
| Chromosome | 17p11.2 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Pathways | NF-κB |
| UniProt ID | P36956 |
| NCBI Gene ID | 6720 |
| Ensembl ID | ENSG00000172318 |
| OMIM | 184756 |
| SREBP1a | More potent transcription factor, wider target gene range |
| SREBP1c | Primarily regulates fatty acid synthesis, insulin-responsive |
| Sterol-sensing domain | Responds to sterol levels |
| C-terminal regulatory domain | Interactions with SCAP and INSIG |
| Insulin signaling | PI3K/Akt pathway activates SREBP1c |
| Glucose | ChREBP cooperation |
| Associated Diseases | AD, ADH, Aging, Als, Alzheimer |
| Known Drugs/Compounds | rapamycin |
| Interactions | A2M, ACACA, ACOX1, Adiponectin, ADIPOQ, ALDH2 |
| KG Connections | 596 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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