gene 1,286 words KG: SMN2
Contents

SMN2 Gene

🧬 Gene Info
Gene SymbolSMN2
Full NameSurvival of Motor Neuron 2, Telomeric
Chromosome5q13.2.
FunctionThe SMN complex plays a critical role in pre-mRNA splicing by facilitating the biogenesis of U1, U2, U4, and U5 snRNPs[@pellizzoni2002].
Molecular Weight32 kDa
Amino Acids294 aa
UniProt IDQ16637
NCBI Gene ID6609
Ensembl IDENSG00000120247
OMIM601627
GeneCardsSMN2
Human Protein AtlasSMN2
Associated DiseasesAls
InteractionsAND, MOTOR NEURONS, NEURON, Rb, SMN1
KG Connections23 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

blarcamesine-axon
clinical_trial · KG edge: therapeutic_target
NeuRon Therapeutics
company · KG edge: interacts_with
Neurodegeneration
disease · KG edge: implicated_in
SMN1 - Survival Motor Neuron 1
gene · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

SMN2 expressed_in SMN1
SMN2 therapeutic_target Mrna Processing
SMN1 interacts_with SMN2
SMN associated_with SMN2
SMN2 interacts_with SMN1
SMN2 interacts_with Spinal Muscular Atrophy
SMN2 interacts_with Rb
AXON therapeutic_target SMN2
SMN2 therapeutic_target MOTOR NEURONS
SMN2 therapeutic_target NEURON

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)