concept

RNA SPLICING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RNA SPLICING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

131Connections

0Hypotheses

0Analyses

33Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	RNA SPLICING
Key Genes/Proteins	AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS, AND, C9ORF72, CHMP7, DEMENTIA
Related Diseases	Aging, ALS, Amyotrophic Lateral Sclerosis, Dementia, Frontotemporal Dementia
Related Pathways	Mitochondrial Function

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RNA Splicing in Neurodegeneration

mechanism · 1405 words

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Pathway Diagram

graph TD
    RNA_SPLICING["RNA SPLICING"]
    PRMT["PRMT"] -->|"regulates"| RNA_SPLICING
    TDP_43["TDP-43"] -->|"involved_in"| RNA_SPLICING
    CYTOKINES["CYTOKINES"] -->|"activates"| RNA_SPLICING
    P53["P53"] -->|"activates"| RNA_SPLICING
    IL_6["IL-6"] -->|"activates"| RNA_SPLICING
    Aging["Aging"] -->|"activates"| RNA_SPLICING
    Als["Als"] -->|"activates"| RNA_SPLICING
    Tumor["Tumor"] -->|"activates"| RNA_SPLICING
    APOPTOSIS["APOPTOSIS"] -->|"inhibits"| RNA_SPLICING

Outgoing (33)

Target	Relation	Type	Str
FTLD-TDP C	upregulates	disease	0.93
Frontotemporal Lobar Degeneration with TDP-43 Type C	associated_with	disease	0.90
UBIQUITIN	causes	protein	0.65
Retinal Degeneration	activates	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
ALS	biomarker_for	disease	0.65
Frontotemporal Dementia	causes	disease	0.65
Dementia	causes	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
ALS	causes	disease	0.65
Aging	interacts_with	disease	0.65
MOTOR NEURONS	interacts_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
RNA	associated_with	gene	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
Mitochondrial Function	associated_with	pathway	0.60
SRRM2	causes	gene	0.60
RNA	biomarker_for	gene	0.60
AND	biomarker_for	gene	0.60
RNA	causes	gene	0.60
AND	causes	gene	0.60
Tdp-43	causes	pathway	0.60
TDP-43	causes	gene	0.60
CHMP7	causes	gene	0.60
MYO7A	activates	gene	0.60
Stem Cell	expressed_in	cell_type	0.55
TDP-43	expressed_in	gene	0.55
Neuron	expressed_in	cell_type	0.55
GENE EXPRESSION	interacts_with	concept	0.50
NUCLEUS	associated_with	concept	0.50
UBIQUITIN	expressed_in	gene	0.35
TDP-43	inhibits	gene	0.35

Incoming (98)

Source	Relation	Type	Str
TARDBP	regulates	gene	0.95
TDP-43	involved_in	protein	0.95
Nuclear Speckle	involved_in	cell_type	0.95
TDP-43	modulates	protein	0.95
TDP-43	involved_in	protein	0.95
Tdp-43	regulates	protein	0.92
Nuclear Speckle Dysfunction	inhibits	mechanism	0.90
TDP-43	regulates	protein	0.90
TDP-43	regulates	protein	0.90
TARDBP	regulates	protein	0.90
nuclear speckle dysfunction	dysregulates	process	0.80
CGAS	regulates	gene	0.70
Als	activates	disease	0.70
P53	activates	gene	0.70
CYTOKINES	activates	gene	0.70
IL-6	activates	gene	0.70
Aging	activates	disease	0.70
TDP-43	regulates	protein	0.70
Tumor	activates	disease	0.70
ASTROCYTES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
NGF	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
SRSF3	activates	gene	0.60
Neurodegeneration	activates	disease	0.60
Senescence	activates	disease	0.60
Alzheimer	activates	disease	0.60
Amyotrophic Lateral Sclerosis	activates	disease	0.60
NCL	activates	gene	0.60
ERK	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
APOPTOSIS	causes	gene	0.60
CANCER	activates	gene	0.60
MYC	causes	gene	0.60
Breast Cancer	causes	disease	0.60
Cancer	activates	disease	0.60
TAU	therapeutic_target	gene	0.60
ALZHEIMER	associated_with	gene	0.60
EGFR	inhibits	gene	0.60
TIA1	inhibits	gene	0.60
GENES	inhibits	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
TAUOPATHY	inhibits	gene	0.60
MYC	inhibits	gene	0.60
Tauopathy	inhibits	disease	0.60
Als	inhibits	disease	0.60
Alzheimer	associated_with	disease	0.60
Longevity	associated_with	disease	0.60
Carcinoma	regulates	disease	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RNA SPLICING in their description or question text

No additional research found