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gene 1,225 words KG: RAB11
Contents

RAB11A — Ras-Related Protein Rab-11A

🧬 Gene Info
Gene SymbolRAB11A
Full NameRas-Related Protein Rab-11A
AliasesPage for RAB11A
FunctionRAB11A functions in the recycling endosome compartment
Molecular Weight24 kDa
Amino Acids216 aa
UniProt IDRAB11A
Ensembl IDENSG00000103740
GeneCardsRAB11A
Human Protein AtlasRAB11A
Endosomal sortingRAB11A sorts synaptic vesicle membrane proteins from early endosomes to recycling endosomes
Synaptic vesicle reformationRAB11A traffics recycling vesicles back to the presynaptic terminal where they are reloaded with neurotransmitter
Synaptic plasticityRAB11A-dependent recycling supports activity-dependent changes in synaptic strength [@bartz2020]
Associated DiseasesAging, Als, Ftd, Neurodegeneration
InteractionsAlbumin, AND, APOE, C1Q, C1Q/C3, COMPLEMENT
KG Connections236 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (15)

SASP-Mediated Complement Cascade Amplification
Score: 0.91Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77

Related Analyses (9)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedDigital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (6)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_withBDNF Gene
gene · KG edge: associated_withBIN1 — Bridging Integrator 1
gene · KG edge: associated_withAlzheimer Indonesia
institution · KG edge: regulatesPackard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

ELAVL2 therapeutic_target RAB11
C1Q inhibits RAB11
MTOR therapeutic_target RAB11
CLPP therapeutic_target RAB11
RAB11 therapeutic_target STX17
RAB11 inhibits RAB5
RAB11 therapeutic_target SNAP29
RAB11 therapeutic_target IGF2BP1
RAB11 therapeutic_target LONP1
RAB11 therapeutic_target BDNF

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