| Gene Symbol | PRDX3 |
| Full Name | Peroxiredoxin 3 |
| Chromosome | 10q26.11 |
| Function | is a mitochondrial member of the peroxiredoxin family of antioxidant enzymes that specifically reduces hydrogen peroxide (H₂O₂) and organic hydroperoxides[@rhee2001]. |
| Exons | 7 |
| Pathways | senescence |
| Ensembl ID | ENSG00000115651 |
| GeneCards | PRDX3 |
| Human Protein Atlas | PRDX3 |
| Catalytic cysteine (Cys47) | Peroxide-reducing active site |
| Resolving cysteine (Cys127) | Forms disulfide during catalytic cycle |
| TPx_2 domain | Characteristic of typical 2-Cys peroxiredoxins |
| Peroxide reduction | 2-Cys catalytic mechanism reducing H₂O₂ to H₂O |
| Redox signaling regulation | Controls localized H₂O₂ concentrations |
| Protection of mitochondrial proteins | Prevents oxidative damage to respiratory chain components[@li2007] |
| Associated Diseases | Als, Alzheimer |
| Interactions | Actin, ALZHEIMER, APOE, APP, BLM, CALB1 |
| KG Connections | 95 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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