Contents

PLIN3 Gene

🧬 Gene Info

Gene Symbol	PLIN3
Function	encodes a lipid droplet-associated protein that plays crucial roles in lipid metabolism, autophagy regulation, and lysosomal function.
Primary Expression	various tissues with specific patterns:
Molecular Weight	47 kDa
Pathways	autophagy pathway, Phagocytosis, Mtor, Autophagy, complement cascade
Ensembl ID	ENSG00000138326
GeneCards	PLIN3
Human Protein Atlas	PLIN3
Coats lipid droplet surface	Forms a monomolecular layer on the droplet surface
Regulates size	Controls lipid droplet growth and coalescence
Prevents lipolysis	Protects stored triglycerides from ATGL-mediated hydrolysis
Recruits proteins	Attracts lipases and other regulatory proteins
Lipid droplet recognition	PLIN3 marks droplets for selective autophagy
Autophagosome recruitment	Facilitates LC3 binding to lipid droplets
Lysosomal fusion	Coordinates droplet delivery to lysosomes
Associated Diseases	neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	ACOX1, Adiponectin, ADIPOQ, AMPK, AND, ASTROCYTES
KG Connections	206 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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