gene

CSNK1D

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CSNK1D: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections
0Hypotheses
1Analyses
20Outgoing
1Incoming
0Experiments
1Debates

Summary

CSNK1D encodes casein kinase 1 delta, a serine/threonine kinase involved in circadian rhythm regulation, tau phosphorylation, and neurodegenerative disease pathogenesis.

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🧬 Gene Info
Gene SymbolCSNK1D
Full NameCasein Kinase 1 Delta
Chromosome15q21.3
Protein TypeKinase
Functionis a serine/threonine protein kinase that plays critical roles in multiple cellular processes, including circadian rhythm regulation, Wnt signaling, DNA damage response, and protein trafficking.
Primary ExpressionBrain (hypothalamus, SCN, cortex, hippocampus), liver, lung
Molecular Weight47 kDa
Amino Acids409 aa
PathwaysWnt signaling, wnt
UniProt IDP48730
NCBI Gene ID1453
Ensembl IDENSG00000141552
OMIM604065
GeneCardsCSNK1D
Human Protein AtlasCSNK1D
Associated DiseasesAlzheimer's disease, Parkinson's disease, Huntington's disease
InteractionsALS, AMYOTROPHIC LATERAL SCLEROSIS, CSNK1E, GAPVD1, MOTOR NEURONS, PER1
KG Connections21 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CSNK1D — AlphaFold P48730 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CSNK1D - Casein Kinase 1 Delta

gene · 2701 words

CSNK1D Protein (Casein Kinase 1 Delta)

protein · 1511 words

Pathway Diagram

graph TD
    CSNK1D["CSNK1D"]
    Wnt___catenin_pathway(["Wnt/beta-catenin pathway"])
    CSNK1D -->|"activates"| Wnt___catenin_pathway
    Hedgehog_GLI_pathway(["Hedgehog-GLI pathway"])
    CSNK1D -->|"activates"| Hedgehog_GLI_pathway
    SHH["SHH"]
    CSNK1D -->|"regulates"| SHH
    PTCH1["PTCH1"]
    CSNK1D -->|"regulates"| PTCH1
    Oxidative_phosphorylation["Oxidative phosphorylation"]
    CSNK1D -->|"regulates"| Oxidative_phosphorylation
    TDP_43["TDP-43"]
    CSNK1D -->|"phosphorylates"| TDP_43
    GAPVD1["GAPVD1"]
    CSNK1D -->|"phosphorylates"| GAPVD1
    Ciliogenesis["Ciliogenesis"]
    CSNK1D -->|"participates in"| Ciliogenesis
    Cell_proliferation["Cell proliferation"]
    CSNK1D -->|"regulates"| Cell_proliferation
    Cell_migration["Cell migration"]
    CSNK1D -->|"regulates"| Cell_migration
    Cell_invasion["Cell invasion"]
    CSNK1D -->|"regulates"| Cell_invasion
    HLA_A["HLA-A"]
    CSNK1D -->|"associated with"| HLA_A
    MOTOR_NEURONS["MOTOR NEURONS"]
    MOTOR_NEURONS -->|"inhibits"| CSNK1D
    style CSNK1D fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (20)

TargetRelationTypeStr
Cell invasionregulatesbiological_process0.80
Wnt/β-catenin pathwayactivatespathway0.80
Hedgehog-GLI pathwayactivatespathway0.80
SHHregulatesgene0.80
PTCH1regulatesgene0.80

Incoming (1)

SourceRelationTypeStr
MOTOR NEURONSinhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Can circadian interventions reverse microglial priming independent of sleep disr

chronobiology | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Can circadian interventions reverse microglial priming independent of sleep disr

closed · Rounds: 4 · Score: 0.95 · 2026-04-10