gene 604 words KG: PER1
Contents

PER1 Gene

🧬 Gene Info
Gene SymbolPeriod Circadian Regulator 1
Chromosome17p13.1
FunctionPER1 (Period Circadian Regulator 1) is a core component of the mammalian circadian clock.
Molecular Weight136 kDa
PathwaysAmyloid, Mtor, Pi3K/Akt, circadian regulation
UniProt IDO15055
NCBI Gene ID5441
Ensembl IDENSG00000132359
OMIM602260
Associated DiseasesALS, autism spectrum disorder
Known Drugs/Compoundslithium
InteractionsAKT, APP, BMAL1, CLOCK, CRY1, CRY2
KG Connections145 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (12)

Multi-Modal Stress Response Harmonization
Score: 0.76
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Circadian Clock-Autophagy Synchronization
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (9)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

Related Experiments (2)

Circadian gene expression effects of SD vs ketamine
exploratory · proposed · Score: 0.95
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

FMR1 — Fragile X Messenger Ribonucleoprotein 1
gene · KG edge: activates
Alzheimer Indonesia
institution · KG edge: expressed_in
BMAL1 (ARNTL) Gene
gene · KG edge: associated_with
CRY2 Gene
gene · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: expressed_in

Knowledge Graph (12 edges)

PER1 regulates CRY2
PER1 regulates PER2
PER1 regulates CLOCK
PER1 regulates BMAL1
PER1 expressed_in SIRT1
CRY1 interacts_with PER1
CLOCK interacts_with PER1
CLOCK associated_with PER1
BMAL1 associated_with PER1
PER1 expressed_in AKT

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