Contents

TP53 Gene

🧬 Gene Info

Gene Symbol	TP53
Full Name	Tumor Protein P53
Chromosome	17p13.1
Function	p53 regulates cell cycle arrest, DNA repair, and apoptosis in response to cellular stress.
Primary Expression	all neuronal populations including: - Cortical neurons (layer 2-6) - Hippocampal neurons (CA1-CA3, dentate gyrus granule cells) - Dopaminergic neurons
Amino Acids	393 aa
Exons	11
Pathways	Akt, Apoptosis, Autophagy, Blood-Brain Barrier, Cell Cycle
UniProt ID	[P04637](https://www.uniprot.org/uniprot/P04637)
Ensembl ID	ENSG00000141510
GeneCards	TP53
Human Protein Atlas	TP53
N-terminal Transactivation Domain (TAD)	Residues 1-61, interacts with transcriptional coactivators (CBP/p300, MDM2)
Proline-Rich Domain (PRR)	Residues 64-92, contains PXXP motifs for protein-protein interactions
Central DNA-Binding Domain (DBD)	Residues 102-292, recognizes p53 consensus DNA response elements
Associated Diseases	acute myeloid leukemia, AD, adverse-risk disease, age-related illness, Aging, ALI
Known Drugs/Compounds	anti-cancer drugs, CHRYSOTIXINE, Emodin, Mifepristone, PC14586, PMIγ
Interactions	ACAT1, ACHE, ACOX1, ACSL4, ACTB, ACVR2A
SciDEX Hypotheses	Epigenetic Silencing of Tumor Suppressor Genes in
KG Connections	2461 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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