pathway

OXIDATIVE PHOSPHORYLATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OXIDATIVE PHOSPHORYLATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1299Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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🔀 Pathway Info

Name	OXIDATIVE PHOSPHORYLATION
Key Genes/Proteins	ABCA7, AKT1, ALPHA-SYNUCLEIN, AMPK, AMYLOID, APOE
Related Diseases	ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, APOPTOSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Oxidative Phosphorylation (OXPHOS)

pathway · 635 words

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Pathway Diagram

graph TD
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    style OXIDATIVE_STRESS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| TCA_CYCLE["TCA CYCLE"]
    style TCA_CYCLE fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| PI3K["PI3K"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| RAS["RAS"]
    style RAS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| RB1["RB1"]
    style RB1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| RIPK1["RIPK1"]
    style RIPK1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| SQSTM1["SQSTM1"]
    style SQSTM1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    COMPLEMENT["COMPLEMENT"] -->|"activates"| OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    style COMPLEMENT fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    IMMUNE_RESPONSE["IMMUNE RESPONSE"] -->|"activates"| OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    style IMMUNE_RESPONSE fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    DENDRITIC_CELL["DENDRITIC CELL"] -->|"activates"| OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    style DENDRITIC_CELL fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    DNA_DAMAGE["DNA DAMAGE"] -->|"activates"| OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    style DNA_DAMAGE fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    EGF["EGF"] -->|"activates"| OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    style EGF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style OXIDATIVE_PHOSPHORYLATION fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (189)

Target	Relation	Type	Str
Chronic Tendon Injury	therapeutic_target	disease	0.95
Tendon Homeostasis	associated_with	process	0.90
LIPID DROPLET ACCUMULATION	inhibits	phenotype	0.90
Lung Cancer Brain Metastasis	involved_in	disease	0.90
Necroptosis	suppresses	process	0.85
aging	associated_with	phenotype	0.75
Ovarian Cancer	downregulates	disease	0.75
BMAL1	regulates	gene	0.70
NECROPTOSIS	causes	phenotype	0.65
PYROPTOSIS	inhibits	phenotype	0.65
PYROPTOSIS	activates	phenotype	0.65
MICROGLIA	treats	cell_type	0.65
PYRUVATE	activates	phenotype	0.65
SQSTM1	phosphorylates	gene	0.65
CYTOKINES	interacts_with	phenotype	0.65
ASTROCYTES	produces	cell_type	0.60
Pi3K	interacts_with	pathway	0.55
Akt	interacts_with	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Glycolysis	interacts_with	pathway	0.55
Nf-Κb	interacts_with	pathway	0.55
Wnt	interacts_with	pathway	0.55
Mapk	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
Reactive Oxygen Species	activates	process	0.50
NUCLEUS	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
T Cell	activates	cell_type	0.50
Epithelial	activates	cell_type	0.50
MTDNA	associated_with	gene	0.50
disease	activates	disease	0.50
DNA DAMAGE	activates	concept	0.50
Dendritic Cell	activates	cell_type	0.50
MITOCHONDRIAL DNA	associated_with	gene	0.50
CELL CYCLE	regulates	cell_type	0.50
Neuroprotection	inhibits	process	0.50
COLORECTAL CANCER	activates	disease	0.50
CYP1A1	activates	concept	0.50
HIPPO	interacts_with	concept	0.50
CELL DEATH	activates	concept	0.50
Microrna	activates	pathway	0.50
Inflammatory Bowel Disease	activates	disease	0.50
MTORC1	activates	concept	0.50
Endothelial	activates	cell_type	0.50
RAPAMYCIN	activates	drug	0.50
Stem Cell	activates	cell_type	0.50
Epithelial Cell	activates	cell_type	0.50
GLYCOLYSIS	associated_with	pathway	0.50
GLYCOLYSIS	activates	pathway	0.50
GLYCOLYSIS	inhibits	pathway	0.50

Incoming (1110)

Source	Relation	Type	Str
Als	activates	disease	1.00
ATP	associated_with	gene	1.00
Tumor	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
Cancer	regulates	disease	1.00
CANCER	regulates	gene	1.00
Als	regulates	disease	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
Cancer	activates	disease	1.00
AKT	activates	gene	1.00
Tumor	activates	disease	1.00
Inflammation	regulates	disease	1.00
OXIDATIVE STRESS	activates	gene	1.00
MITOCHONDRIA	associated_with	gene	1.00
APOPTOSIS	regulates	gene	1.00
PI3K	activates	gene	1.00
ATP	activates	gene	1.00
Tumor	inhibits	disease	1.00
CANCER	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
ROS	activates	gene	1.00
Als	therapeutic_target	disease	1.00
Inflammation	activates	disease	1.00
GENES	activates	gene	1.00
MTOR	activates	gene	1.00
INFLAMMATION	regulates	gene	1.00
MITOPHAGY	regulates	gene	1.00
Obesity	activates	disease	1.00
MITOCHONDRIAL DYSFUNCTION	treats	gene	1.00
CANCER	inhibits	gene	1.00
Astrocytic Mitochondria	involved_in	cell_type	0.95
MITOCHONDRIA	associated_with	cell_type	0.95
Mtdna	associated_with	biomarker	0.95
mtDNA	involved_in	biomarker	0.95
Tumor	regulates	disease	0.95
Inflammasome	downregulates	process	0.95
PPARGC1A	mediates	gene	0.95
Gamitrinib	inhibits	drug	0.95
COX6B1	activates	protein	0.90
PPARGC1A	associated_with	gene	0.90
Early Metastatic Epithelial Cell Clusters	involved_in	cell_type	0.90
NDUFA12	involved_in	gene	0.90
MT-ND1	involved_in	gene	0.90
COX15	involved_in	gene	0.90
Mitochondrial Genome	associated_with	biomarker	0.90
COX4I1	involved_in	gene	0.90
ALZHEIMER	activates	gene	0.90
INFLAMMATION	activates	gene	0.90
CYTOKINES	activates	gene	0.90
Cancer	inhibits	disease	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Which specific metabolic pathways in APOE4+ microglia are most therapeutically t

neurodegeneration | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While APOE4 disrupts microglial metabolism broadly, the debate didn't identify w

closed · Rounds: 4 · Score: 0.92 · 2026-04-09

Related Research

Hypotheses and analyses mentioning OXIDATIVE PHOSPHORYLATION in their description or question text

No additional research found