| Gene Symbol | NR4A2 |
| Chromosome | 2q22.1 |
| Protein Type | Receptor |
| Function | It acts upstream of PITX3, LMX1A, and FOXA2 in the developmental cascade that generates dopaminergic neurons. |
| Primary Expression | ventricular and subventricular zones of the midbrain, where it specifies dopaminergic neuron fate |
| Amino Acids | 598 aa |
| Exons | 8 |
| Pathways | Jak-Stat |
| Ensembl ID | ENSG00000153234 |
| GeneCards | NR4A2 |
| Human Protein Atlas | NR4A2 |
| DNA-Binding Domain (DBD) | Two zinc finger motifs that recognize NGFI-B response elements (NBREs) and Nur response elements (NurREs) |
| Ligand-Binding Domain (LBD) | A hydrophobic cavity that, unlike classical nuclear receptors, does not bind traditional ligands but may interact with coactivators |
| AF-2 Domain | A transcriptional activation function region in the LBD required for coactivator recruitment |
| N-terminal Domain | Contains a transactivation function (AF-1) region with multiple phosphorylation sites |
| Associated Diseases | neurodegeneration |
| Interactions | APOPTOSIS, App, CANCER, CCL2, CD8, CX3CR1 |
| KG Connections | 102 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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