concept

NITRIC OXIDE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NITRIC OXIDE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

121Connections

0Hypotheses

0Analyses

29Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	NITRIC OXIDE
Key Genes/Proteins	AKT, CLU, GFAP, JNK
Related Diseases	AGING, INFLAMMATION, NEURODEGENERATION, OXIDATIVE STRESS

Pathway Diagram

graph TD
    NITRIC_OXIDE[NITRIC OXIDE]
    NITRIC_OXIDE -->|inhibits| Endothelial_Dysfunction[Endothelial Dysfunction]
    NITRIC_OXIDE -->|released_by| endothelial_cells[endothelial cells]
    NITRIC_OXIDE -->|modulates| Vascular_Remodelling[Vascular Remodelling]
    NITRIC_OXIDE -->|mediates| Antibacterial_Response[Antibacterial Response]
    NITRIC_OXIDE -->|mediates| Bacteria[Bacteria]
    NITRIC_OXIDE -->|released_by| astrocytes[astrocytes]
    NITRIC_OXIDE -->|released_by| macrophages[macrophages]
    NITRIC_OXIDE -->|phosphorylates| TAU[TAU]
    Asymmetric_Dimethyl_Arginine[Asymmetric Dimethyl Arginine] -->|inhibits| NITRIC_OXIDE
    SODs[SODs] -.protects against.-> NITRIC_OXIDE
    CREB[CREB] -->|activates| NITRIC_OXIDE
    ROS[ROS] -->|activates| NITRIC_OXIDE
    CLU[CLU] -->|inhibits| NITRIC_OXIDE
    AKT[AKT] -->|interacts| NITRIC_OXIDE
    TLR4[TLR4] -->|causes| NITRIC_OXIDE
    MICROGLIA[MICROGLIA] -->|produces| NITRIC_OXIDE

Outgoing (29)

Target	Relation	Type	Str
Endothelial Dysfunction	inhibits	process	0.90
endothelial cells	released_by	cell_type	0.90
Vascular Remodelling	modulates	process	0.85
Bacteria	mediates	organism	0.85
Antibacterial Response	mediates	process	0.85
Endothelial Dysfunction	protects_against	phenotype	0.85
macrophages	released_by	cell_type	0.70
astrocytes	released_by	cell_type	0.70
OXIDATIVE STRESS	interacts_with	phenotype	0.65
TAU	phosphorylates	protein	0.65
TAU	exacerbates	protein	0.65
JNK	activates	gene	0.65
GFAP	activates	gene	0.65
CHOROID PLEXUS	inhibits	brain_region	0.65
ASTROCYTES	causes	cell_type	0.65
ASTROCYTES	treats	cell_type	0.65
NEURODEGENERATION	causes	disease	0.65
INFLAMMATION	activates	phenotype	0.65
OXIDATIVE STRESS	inhibits	phenotype	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
blood-brain barrier	active_in	brain_region	0.60
microglia	released_by	cell_type	0.60
neural stem cells	released_by	cell_type	0.60
ASTROCYTES	participates_in	cell_type	0.55
CORTEX	associated_with	brain_region	0.45
BRAINSTEM	associated_with	brain_region	0.45
METFORMIN	associated_with	drug	0.45
PONS	associated_with	brain_region	0.45
RAPAMYCIN	associated_with	drug	0.45

Incoming (92)

Source	Relation	Type	Str
Asymmetric Dimethyl Arginine	inhibits	compound	0.85
SODs	protects_against	protein	0.80
CREB	activates	gene	0.70
ROS	activates	gene	0.70
AKT	interacts_with	gene	0.65
AKT	activates	gene	0.65
AKT	regulates	gene	0.65
AGING	interacts_with	phenotype	0.65
TLR4	causes	gene	0.65
CLU	inhibits	gene	0.65
MICROGLIA	produces	cell_type	0.65
METFORMIN	treats	drug	0.65
MAPK	associated_with	gene	0.60
MTOR	activates	gene	0.60
C1Q	activates	gene	0.60
SQSTM1	activates	gene	0.60
LC3	activates	gene	0.60
SIRT3	regulates	gene	0.60
VEGF	activates	gene	0.60
PI3K	activates	gene	0.60
VEGF	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
KCNK2	expressed_in	gene	0.60
GLP1R	activates	gene	0.60
SIRT1	activates	gene	0.60
LC3	interacts_with	gene	0.60
migraine	disrupts	disease	0.60
neurodegeneration	disrupts	disease	0.60
CREB	inhibits	gene	0.60
CREB	disrupts	gene	0.60
glioblastoma	disrupts	disease	0.60
STING1	activates	gene	0.60
TFEB	activates	gene	0.60
FOXO1	regulates	gene	0.60
spinal muscular atrophy	disrupts	disease	0.60
TP53	activates	gene	0.60
SREBF2	activates	gene	0.60
STX17	activates	gene	0.60
GLP1R	regulates	gene	0.60
SIRT1	regulates	gene	0.60
TP53	regulates	gene	0.60
SREBF2	regulates	gene	0.60
STX17	regulates	gene	0.60
STING1	regulates	gene	0.60
TFEB	regulates	gene	0.60
ULK1	regulates	gene	0.60
BECN1	regulates	gene	0.60
PLIN2	regulates	gene	0.60
LAMP2	regulates	gene	0.60
NFE2L2	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NITRIC OXIDE in their description or question text

No additional research found