Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Bacteria: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Macrophages | associated_with | cell_type | 0.95 |
| Lc3-Associated Phagocytosis | targets | process | 0.85 |
| Autophagy | targets | process | 0.85 |
| Antimicrobial Metabolites | targets | compound | 0.85 |
| Guanylate-Binding Proteins | targets | protein | 0.85 |
| Antimicrobial Peptides | targets | compound | 0.85 |
| Nitric Oxide | mediates | compound | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Bacterial Curli Amyloid → Nucleation of α-Synuclein Misfoldi | 0.720 | neurodegeneration | What are the mechanisms by which gut mic |
| SCFA-Producing Bacterial Depletion → Loss of Neuroprotective | 0.700 | neurodegeneration | What are the mechanisms by which gut mic |
| Bacterial Tyramine–Induced DOPAL Accumulation in Enteric Neu | 0.680 | neurodegeneration | What are the mechanisms by which gut mic |
| Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro | 0.642 | neurodegeneration | What are the mechanisms by which gut mic |
| Bacterial Enzyme-Mediated Dopamine Precursor Synthesis | 0.384 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Levodopa-Induced Dyskinesias Mechanism — Experiment Design | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $2,280,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Computational examination of magainin-I-KL mediated disruption of E. coli biofil [PMID:41724836] | Vinutha AS, Akshay S, Sree Agash SG, Cha | Archives of microbiology | 2026 | 0 |
| The cytoplasmic protein YedX is a potent inhibitor of CsgA amyloid assembly in E [PMID:41581877] | Gurnani B, Jain N | The Journal of biological chem | 2026 | 0 |
| Gene therapy for Parkinson's disease: current landscape, translational challenge [PMID:41837837] | Evola V, Parmar MS | Expert review of neurotherapeu | 2026 | 0 |
| Biofilm-Associated Amyloid Proteins Linked with the Progression of Neurodegenera [PMID:40141340] | Singh AA, Khan F, Song M | International journal of molec | 2025 | 0 |
| E.coli-derived CsgA-peptides stimulate cytokine production in microglia and lead [PMID:41476670] | Mygind L, Jensen G, Neesgaard V, Krohn K | Brain, behavior, & immunity - | 2025 | 0 |
| Neurosurgical gene therapy for central nervous system diseases. [PMID:39191071] | Patel RV, Nanda P, Richardson RM | Neurotherapeutics : the journa | 2024 | 0 |
| [WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] | Wieschollek S, Forster S, Megerle K | Handchirurgie, Mikrochirurgie, | 2022 | 0 |
| Long-term efficacy and safety of eladocagene exuparvovec in patients with AADC d [PMID:34763085] | Tai CH, Lee NC, Chien YH, Byrne BJ, Mura | Molecular therapy : the journa | 2022 | 0 |
| Using Caenorhabditis elegans to Model Therapeutic Interventions of Neurodegenera [PMID:35571084] | Wang C, Zheng C | Frontiers in pharmacology | 2022 | 0 |
| Genome-wide screen identifies curli amyloid fibril as a bacterial component prom [PMID:34413194] | Wang C, Lau CY, Ma F, Zheng C | Proceedings of the National Ac | 2021 | 0 |
| Gene therapy restores dopamine transporter expression and ameliorates pathology [PMID:34011628] | Ng J, Barral S, De La Fuente Barrigon C, | Science translational medicine | 2021 | 0 |
| Current Clinical Applications of In Vivo Gene Therapy with AAVs. [PMID:33309881] | Mendell JR, Al-Zaidy SA, Rodino-Klapac L | Molecular therapy : the journa | 2021 | 0 |
| Targeting autophagy using small-molecule compounds to improve potential therapy [PMID:34729301] | Zhang K, Zhu S, Li J, Jiang T, Feng L, P | Acta pharmaceutica Sinica. B | 2021 | 0 |
| Engineering complex communities by directed evolution. [PMID:33986540] | Chang CY, Vila JCC, Bender M, Li R, Mank | Nature ecology & evolution | 2021 | 0 |
| Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100] | Tajika T, Kuboi T, Endo F, Hatori Y, Sai | Progress in rehabilitation med | 2021 | 0 |
| Graphene bilayers with a twist. [PMID:33208935] | ["Andrei E", "MacDonald A"] | Nature materials | 2020 | 0 |
| Crosstalk Between Alpha-Synuclein and Other Human and Non-Human Amyloidogenic Pr [PMID:32538869] | Werner T, Horvath I, Wittung-Stafshede P | Journal of Parkinson's disease | 2020 | 0 |
| Reconstruction of cell spatial organization from single-cell RNA sequencing data [PMID:32541867] | ["Ren X", "Zhong G", "Zhang Q", "Zhang L | Cell research | 2020 | 0 |
| 7-Ketocholesterol- and 7β-Hydroxycholesterol-Induced Peroxisomal Disorders in Gl [PMID:33417205] | ["Nury T", "Yammine A", "Menetrier F", " | Advances in experimental medic | 2020 | 0 |
| Gene therapy for neurodegenerative disorders: advances, insights and prospects. [PMID:32963936] | Chen W, Hu Y, Ju D | Acta pharmaceutica Sinica. B | 2020 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Bacteria in their description or question text
No additional research found