protein

ALKBH5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALKBH5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

0Hypotheses

0Analyses

50Outgoing

18Incoming

0Experiments

0Debates

Summary

Page for ALKBH5 Protein (AlkB Homolog 5)

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🔬 Protein Info

Gene Symbol	ALKBH5
Aliases	AlkB Homolog 5
Function	ALKBH5 (AlkB Homolog 5) is a 259-amino acid nuclear protein that functions as an N6-methyladenosine (m6A) demethylase.
Subcellular Localization	</strong> Nucleus</div> <div class="infobox-row"><strong>Protein Family:</stro
Molecular Weight	29.4 kDa
Amino Acids	259 aa
Pathways	Spermatogenesis
GeneCards	ALKBH5
Human Protein Atlas	ALKBH5
m6A Demethylation	ALKBH5 removes m6A modifications from mRNA, regulating RNA stability, splicing, and translation
Synaptic Plasticity	ALKBH5 activity regulates synaptic protein synthesis and affects learning and memory formation
Neuronal Development	m6A demethylation by ALKBH5 regulates the expression of neurodevelopmental genes
Stress Response	ALKBH5 is recruited to stress granules under cellular stress, where it demethylates mRNAs involved in stress response
Small Molecule Modulators	Selective ALKBH5 inhibitors are being developed for cancer and neurological applications
m6A Homeostasis Restoration	Modulating ALKBH5 activity could restore normal m6A levels in disease states
Associated Diseases	Fertility, Male Infertility, neurodegeneration, Parkinson, Parkinson'S Disease
Known Drugs/Compounds	N6-Methyladenosine
Interactions	APOPTOSIS, GENES, JUN, P53, RNA, TP53
KG Connections	70 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ALKBH5 Protein (AlkB Homolog 5)

protein · 741 words

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Pathway Diagram

graph TD
    ALKBH5(["ALKBH5"])
    MRNA["MRNA"]
    N_6__methyladenosine["N(6)-methyladenosine"]
    N6_Methyladenosine["N6-Methyladenosine"]
    RNA_Methylation["RNA Methylation"]
    astrocytes["astrocytes"]
    MRNA_EXPORT["MRNA EXPORT"]
    mRNA_Metabolism["mRNA Metabolism"]
    Fertility["Fertility"]
    m6A_Modification["m6A Modification"]
    mRNA_Export["mRNA Export"]
    Male_Fertility["Male Fertility"]
    SLC1A2["SLC1A2"]
    depression_related_behaviors["depression-related behaviors"]
    environmental_stress["environmental stress"]
    APOPTOSIS["APOPTOSIS"]
    TP53["TP53"]
    Spermatogenesis["Spermatogenesis"]
    major_depressive_disorder["major depressive disorder"]
    Cancer["Cancer"]
    ALS["ALS"]
    ALKBH5 -->|"regulates"| MRNA
    ALKBH5 -->|"catalyzes"| N_6__methyladenosine
    ALKBH5 -->|"catalyzes"| N6_Methyladenosine
    ALKBH5 -->|"regulates"| RNA_Methylation
    ALKBH5 -->|"expressed in"| astrocytes
    ALKBH5 -->|"modulates"| MRNA_EXPORT
    ALKBH5 -->|"regulates"| mRNA_Metabolism
    ALKBH5 -.-|"associated"| Fertility
    ALKBH5 -->|"modulates"| m6A_Modification
    ALKBH5 -->|"modulates"| mRNA_Export
    ALKBH5 -.-|"associated"| Male_Fertility
    ALKBH5 -->|"regulates"| SLC1A2
    ALKBH5 -->|"modulates"| depression_related_behaviors
    environmental_stress -->|"activates"| ALKBH5
    ALKBH5 -->|"regulates"| APOPTOSIS
    ALKBH5 -.-|"associated"| TP53
    ALKBH5 -->|"involved in"| Spermatogenesis
    ALKBH5 -->|"biomarker_for"| major_depressive_disorder
    ALKBH5 -->|"contributes_to"| Cancer
    ALKBH5 -->|"contributes_to"| ALS
    style ALKBH5 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (57)

Target	Relation	Type	Str
astrocytes	expressed_in	cell_type	0.95
N6-Methyladenosine	modulates	compound	0.95
Male Infertility	associated_with	phenotype	0.95
MRNA	regulates	entity	0.95
MRNA EXPORT	modulates	entity	0.90
Rna Metabolism	regulates	process	0.90
depression-related behaviors	modulates	phenotype	0.90
m6A	demethylates	modification	0.90
m6A	increases	modification	0.90
Fertility	associated_with	phenotype	0.90
SLC1A2	regulates	gene	0.90
Mrna Export	regulates	process	0.90
Male Fertility	associated_with	phenotype	0.90
mRNA Metabolism	regulates	process	0.90
m6A modification	inhibits	process	0.90
male fertility	regulates	phenotype	0.90
APOPTOSIS	regulates	entity	0.88
TP53	associated_with	entity	0.85
Parkinson'S Disease	implicated_in	disease	0.85
m6A methylation	regulates	process	0.85
Mrna Processing	regulates	process	0.85
major depressive disorder	biomarker_for	disease	0.85
RNA metabolism	impacts	process	0.80
Mouse fertility	impacts	process	0.80
Spermatogenesis	regulates	process	0.80
mRNA processing factors	modulates	protein	0.80
nuclear speckles	modulates	cell_type	0.75
TP53	regulates	gene	0.75
TP53	interacts_with	gene	0.70
ALS	contributes_to	disease	0.65
Cancer	contributes_to	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
IGF2BP1	contributes_to	gene	0.60
Igf	therapeutic_target	protein	0.60
FTO	associated_with	gene	0.60
Ras	associated_with	protein	0.60
Rb	associated_with	protein	0.60
METTL3	associated_with	gene	0.60
YTHDF1	contributes_to	gene	0.60
CANCER	contributes_to	gene	0.60
RNA	associated_with	gene	0.60
neurodegeneration	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
RNA	therapeutic_target	gene	0.60
RNA	expressed_in	gene	0.60
neurons	expressed_in	cell_type	0.60
HNRNPA2B1	therapeutic_target	gene	0.60
METTL3	expressed_in	gene	0.60
RNA	activates	gene	0.60

Incoming (18)

Source	Relation	Type	Str
environmental stress	activates	process	0.90
spermatogenesis	associated_with	process	0.85
GENES	activates	gene	0.60
GENES	contributes_to	gene	0.60
HNRNPA2B1	contributes_to	gene	0.60
WTAP	associated_with	gene	0.60
RNA	contributes_to	gene	0.60
IGF2BP1	contributes_to	gene	0.60
CANCER	contributes_to	gene	0.60
METTL3	associated_with	gene	0.60
YTHDF1	contributes_to	gene	0.60
APOPTOSIS	activates	gene	0.60
RNA	activates	gene	0.60
JUN	activates	gene	0.60
P53	activates	gene	0.60
FTO	associated_with	gene	0.60
RNA	therapeutic_target	gene	0.60
HNRNPA2B1	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ALKBH5 in their description or question text

No additional research found