concept

M6A MODIFICATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about M6A MODIFICATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

47Connections

1Hypotheses

0Analyses

29Outgoing

18Incoming

0Experiments

0Debates

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💡 Concept Info

Name	M6A MODIFICATION

Pathway Diagram

graph TD
    M6A_MODIFICATION["M6A MODIFICATION"]
    M6A_MODIFICATION -->|"regulates"| Rna_Metabolism["Rna Metabolism"]
    M6A_MODIFICATION -->|"modulates"| Neuronal_Function["Neuronal Function"]
    M6A_MODIFICATION -->|"modulates"| PIEZO2["PIEZO2"]
    M6A_MODIFICATION -->|"modulates"| RNA["RNA"]
    M6A_MODIFICATION -->|"contributes to"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    M6A_MODIFICATION -->|"contributes to"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    M6A_MODIFICATION -->|"contributes to"| ALS["ALS"]
    M6A_MODIFICATION -->|"involved_in"| Biological_Functions["Biological Functions"]
    METTL3["METTL3"] -->|"catalyzes"| M6A_MODIFICATION
    METTL14["METTL14"] -->|"catalyzes"| M6A_MODIFICATION
    METTL16["METTL16"] -->|"catalyzes"| M6A_MODIFICATION
    YTHDF1["YTHDF1"] -->|"binds"| M6A_MODIFICATION
    YTHDF2["YTHDF2"] -->|"binds"| M6A_MODIFICATION
    YTHDF3["YTHDF3"] -->|"binds"| M6A_MODIFICATION
    FTO["FTO"] -->|"modulates"| M6A_MODIFICATION
    ALKBH5["ALKBH5"] -->|"modulates"| M6A_MODIFICATION

Outgoing (29)

Target	Relation	Type	Str
Rna Metabolism	regulates	process	0.95
Neuronal Function	modulates	process	0.95
PIEZO2	modulates	gene	0.93
R-Loops	regulates	mechanism	0.90
ALZHEIMER'S DISEASE	contributes_to	disease	0.90
PARKINSON'S DISEASE	contributes_to	disease	0.90
ALS	contributes_to	disease	0.90
Cancer	involved_in	disease	0.90
Cancer progression	drives	process	0.90
R-loop	suppresses	process	0.88
Biological Functions	involved_in	process	0.88
HPV early transcript expression	regulates	process	0.87
Hpv Replication	regulates	process	0.85
Phospho-Α-Synuclein	regulates	biomarker	0.85
Dopaminergic Neuron Survival	modulates	process	0.85
Cancer Initiation	involved_in	process	0.85
Cancer Progression	involved_in	process	0.85
Disease	associated_with	disease	0.85
APOPTOSIS	contributes_to	process	0.85
MITOCHONDRIA	modulates	cell_type	0.85
AUTOPHAGY	regulates	process	0.85
ALS	modulates	disease	0.80
INFLAMMATION	modulates	process	0.80
Physiological Functions	involved_in	process	0.80
Pathological Conditions	involved_in	process	0.80
hematopoietic system	regulates	cell_type	0.80
central nervous system	regulates	brain_region	0.80
reproductive system	regulates	cell_type	0.80
Stress Granule Formation	modulates	process	0.80

Incoming (18)

Source	Relation	Type	Str
METTL14	mediates	gene	0.95
YTHDF2	binds	protein	0.95
METTL3	mediates	gene	0.95
YTHDF1	associated_with	protein	0.95
METTL16	catalyzes	enzyme	0.95
YTHDF3	binds	protein	0.95
SETX	activates	gene	0.92
IGF2BP1	binds	protein	0.90
RBM15	involved_in	protein	0.90
FTO	inhibits	gene	0.90
ALKBH5	inhibits	gene	0.90
VIRMA	mediates	gene	0.85
S-adenosylmethionine	associated_with	compound	0.85
WTAP	mediates	gene	0.85
WTAP	regulates	protein	0.85
cell differentiation	upregulates	process	0.85
RBM15	regulates	protein	0.85
Viral Early Transcripts	associated_with	biomarker	0.80

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
METTL3-Mediated m6A Modification of lncRNA-0021 Regulates mi	0.754	molecular neurobiology	View

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning M6A MODIFICATION in their description or question text

No additional research found