gene

DR3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DR3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

23Outgoing

10Incoming

0Experiments

0Debates

Summary

DRD3 — Dopamine Receptor D3

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🧬 Gene Info

Gene Symbol	DRD3
Aliases	Dopamine Receptor D3
Protein Type	Receptor
Function	The DR3 gene encodes a G protein-coupled receptor that The D3 dopamine receptor is a D2-like receptor that plays crucial roles in motor control, reward processing, and cognitive functions.
Subcellular Localization	</th><td>Plasma membrane, postsynaptic density</td></tr>
Pathways	NF-kB signaling, Nf-Κb, Oxidative Stress, oxidative stress response
Ensembl ID	ENSG00000151577
GeneCards	DRD3
Human Protein Atlas	DRD3
Extracellular N-terminus	Contains glycosylation sites and contributes to ligand binding
Intracellular C-terminus	Contains phosphorylation sites for receptor regulation
Third intracellular loop	Important for G protein coupling
Orthosteric binding site	Located within the transmembrane bundle
Allosteric binding sites	Additional sites for modulator binding
Crystal structures available	7R0F, 7RT8
Associated Diseases	Als, Hepatitis, Inflammation, Lupus
Interactions	AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AND, IKK, INFLAMMATION
KG Connections	33 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

D3 Dopamine Receptor Protein

protein · 758 words

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Pathway Diagram

graph TD
    DR3["DR3"]
    Lupus{"Lupus"}
    DR3 -->|"associated_with"| Lupus
    Als{"Als"}
    DR3 -->|"associated_with"| Als
    Hepatitis{"Hepatitis"}
    DR3 -->|"associated_with"| Hepatitis
    Inflammation{"Inflammation"}
    DR3 -->|"associated_with"| Inflammation
    Neuroinflammation{"Neuroinflammation"}
    DR3 -->|"activates"| Neuroinflammation
    Alzheimer{"Alzheimer"}
    DR3 -->|"activates"| Alzheimer
    Aging{"Aging"}
    DR3 -->|"activates"| Aging
    DR3 -->|"activates"| Inflammation
    AND["AND"]
    DR3 -->|"associated_with"| AND
    EGF["EGF"]
    DR3 -->|"associated_with"| EGF
    NF_B["NF-KappaB"]
    DR3 -->|"activates"| NF_B
    INFLAMMATION["INFLAMMATION"]
    DR3 -->|"activates"| INFLAMMATION
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    DR3 -->|"activates"| NEUROINFLAMMATION
    Oxidative_Stress(["Oxidative Stress"])
    DR3 -->|"activates"| Oxidative_Stress
    Nf_b(["Nf-Kappab"])
    DR3 -->|"activates"| Nf_b

Outgoing (23)

Target	Relation	Type	Str
Aging	activates	disease	0.65
Inflammation	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Lupus	associated_with	disease	0.65
Als	associated_with	disease	0.65
Hepatitis	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
EGF	associated_with	gene	0.60
AND	associated_with	gene	0.60
neuroinflammation	activates	disease	0.60
NF-ΚB	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
IKK	inhibits	gene	0.60
IKK	activates	gene	0.60
AND	activates	gene	0.60
AGING	activates	gene	0.60
TAU	activates	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60

Incoming (10)

Source	Relation	Type	Str
INFLAMMATION	associated_with	gene	0.60
ALZHEIMER	activates	gene	0.60
AGING	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AND	activates	gene	0.60
TAU	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
NF-ΚB	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DR3 in their description or question text

No additional research found