gene

HERC6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HERC6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

0Hypotheses

0Analyses

10Outgoing

2Incoming

0Experiments

0Debates

Summary

Comprehensive coverage of HERC6 E3 ubiquitin ligase in antiviral immunity, ISGylation, neurodegenerative diseases including AD/PD, and aging.

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🧬 Gene Info

Gene Symbol	HERC6
Full Name	HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 6
Chromosome	12p13.31
Protein Family	HERC family (HECT and RLD domain containing)
Protein Type	Ligase
Function	is a large E3 ubiquitin ligase that plays critical roles in antiviral immunity, protein quality control, and cellular stress responses [1][2].
Primary Expression	Ubiquitous, high in immune tissues
Subcellular Localization	, including association with membranes and organelles
Molecular Weight	470 kDa
Amino Acids	258 aa
Pathways	mTOR signaling
UniProt ID	Q8IWV1
NCBI Gene ID	55076
Ensembl ID	ENSG00000138650
OMIM	611236
GeneCards	HERC6
Human Protein Atlas	HERC6
Associated Diseases	neurodegeneration
Interactions	IFN
KG Connections	12 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HERC6 — AlphaFold Q8IWV1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HERC6 — HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 6

gene · 2363 words

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Pathway Diagram

graph TD
    HERC6["HERC6"]
    Als{"Als"}
    HERC6 -->|"contributes_to"| Als
    ISG["ISG"]
    HERC6 -->|"degrades"| ISG
    STING["STING"]
    HERC6 -->|"degrades"| STING
    HERC5["HERC5"]
    HERC6 -->|"degrades"| HERC5
    Ubiquitin("Ubiquitin")
    HERC6 -->|"degrades"| Ubiquitin
    UBIQUITIN["UBIQUITIN"]
    HERC6 -->|"contributes_to"| UBIQUITIN
    HERC3["HERC3"]
    HERC6 -->|"contributes_to"| HERC3
    Immune_Response(["Immune Response"])
    HERC6 -->|"contributes_to"| Immune_Response
    T_Cell["T Cell"]
    HERC6 -->|"contributes_to"| T_Cell
    Proteasome("Proteasome")
    HERC6 -->|"contributes_to"| Proteasome
    IFN["IFN"]
    IFN -->|"activates"| HERC6
    HERC5 -->|"contributes_to"| HERC6
    neurodegeneration["neurodegeneration"]
    HERC6 -->|"implicated_in"| neurodegeneration

Outgoing (10)

Target	Relation	Type	Str
Als	contributes_to	disease	0.65
Ubiquitin	degrades	protein	0.60
Immune Response	contributes_to	pathway	0.60
T Cell	contributes_to	cell_type	0.60
Proteasome	contributes_to	protein	0.60
STING	degrades	gene	0.60
HERC5	degrades	gene	0.60
UBIQUITIN	contributes_to	gene	0.60
ISG	degrades	gene	0.60
HERC3	contributes_to	gene	0.60

Incoming (2)

Source	Relation	Type	Str
IFN	activates	gene	0.60
HERC5	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HERC6 in their description or question text

No additional research found