gene

RPS18

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPS18: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

15Outgoing

0Incoming

0Experiments

0Debates

Summary

RPS18 is a gene implicated in neurodegeneration research. Key relationships include: downregulates, upregulates, regulates. Associated with PAAD. Connected to 17 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	RPS18
Full Name	Ribosomal Protein S18
Function	encodes a conserved ribosomal protein component of the 40S small ribosomal subunit.
Subcellular Localization	RPS18 is expressed at high levels throughout the brain, particularly in: - Pyram
GeneCards	RPS18
Human Protein Atlas	RPS18
Ribosomal Assembly	RPS18 participates in the early stages of 40S subunit biogenesis in the nucleolus
Translation Initiation	The protein contributes to the formation of the pre-initiation complex (PIC) that scans mRNA for start codons
tRNA Binding	RPS18 interacts with the A-site of the ribosome, facilitating tRNA accommodation during translation elongation
Quality Control	The protein plays a role in the nonsense-mediated decay (NMD) pathway, recognizing premature termination codons
Associated Diseases	PAAD
Interactions	DDX21
KG Connections	15 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RPS18 — Ribosomal Protein S18

gene · 653 words

→

Pathway Diagram

graph TD
    RPS18["RPS18"]
    DDX21["DDX21"]
    RPS18 -->|"interacts with"| DDX21
    CSFV["CSFV"]
    RPS18 -->|"participates in"| CSFV
    APOD["APOD"]
    RPS18 -->|"downregulates"| APOD
    SORL1["SORL1"]
    RPS18 -->|"downregulates"| SORL1
    SPOCK2["SPOCK2"]
    RPS18 -->|"downregulates"| SPOCK2
    PRSS11["PRSS11"]
    RPS18 -->|"downregulates"| PRSS11
    ID3["ID3"]
    RPS18 -->|"downregulates"| ID3
    RPS2["RPS2"]
    RPS18 -->|"upregulates"| RPS2
    RPS8["RPS8"]
    RPS18 -->|"upregulates"| RPS8
    RPL37A["RPL37A"]
    RPS18 -->|"upregulates"| RPL37A
    ILF3["ILF3"]
    RPS18 -->|"regulates"| ILF3
    IRF7["IRF7"]
    RPS18 -->|"regulates"| IRF7
    style RPS18 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (15)

Target	Relation	Type	Str
CSFV	participates_in	entity	0.90
DDX21	interacts_with	gene	0.90
SPOCK2	downregulates	gene	0.80
PRSS11	downregulates	gene	0.80
ID3	downregulates	gene	0.80
RPS2	upregulates	gene	0.80
RPS8	upregulates	gene	0.80
RPL37A	upregulates	gene	0.80
ILF3	regulates	gene	0.80
IRF7	regulates	gene	0.80
PAAD	associated_with	disease	0.80
M1_macrophage	expressed_in	cell_type	0.80
APOD	downregulates	gene	0.80
SPP1	co_expressed_with	gene	0.80
SORL1	downregulates	gene	0.80

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RPS18 in their description or question text

No additional research found