gene 542 words KG: IRF7
Contents

IRF7 Gene

🧬 Gene Info
Gene SymbolIRF7
Chromosome11p15.5
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight55 kDa
Amino Acids503 aa
Exons9
PathwaysImmune Response, Inflammasome, Jak-Stat, Pyroptosis
NCBI Gene ID3665
GeneCardsIRF7
Human Protein AtlasIRF7
Associated Diseasesneurodegeneration
InteractionsAGING, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE, BRAIN INFLAMMATION
KG Connections100 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (9)

CYP46A1 Overexpression Gene Therapy
Score: 0.98
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (5)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

ATF4 Gene
gene · KG edge: expressed_in
CD68 Gene
gene · KG edge: expressed_in
CGAS Gene
gene · KG edge: activates
CSF1R — Colony Stimulating Factor 1 Receptor
gene · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: activates

Knowledge Graph (12 edges)

JAK2 activates IRF7
IRF7 regulates STING
IRF7 regulates CGAS
RELA expressed_in IRF7
MYC expressed_in IRF7
SP1 expressed_in IRF7
IRF7 expressed_in PPARGC1A
IRF7 expressed_in ATF4
IRF7 expressed_in JUN
IRF7 expressed_in NFKB1

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