| Gene Symbol | LATS1 |
| Full Name | Large Tumor Suppressor Kinase 1, Hippo Pathway |
| Chromosome | 6q25.1 |
| Protein Type | Serine/Threonine Kinase |
| Primary Expression | neural progenitors of the ventricular and subventricular zones, where it controls the balance between proliferation and differentiation |
| Amino Acids | 130 aa |
| Exons | 9 |
| Pathways | Hippo Pathway, Yap/Taz |
| Ensembl ID | ENSG00000131023 |
| GeneCards | LATS1 |
| Human Protein Atlas | LATS1 |
| SNAI1 (Snail) | LATS1 phosphorylation promotes Snail degradation, modulating epithelial-mesenchymal transition and neural crest cell migration |
| DYRK1A | LATS1 interacts with and modulates the activity of DYRK1A, a kinase implicated in Down syndrome and tau phosphorylation |
| p53 | LATS1 stabilizes p53 by phosphorylating MDM2, linking Hippo signaling to DNA damage responses |
| Rab8A | LATS1 phosphorylates Rab8A to regulate ciliogenesis, connecting Hippo to primary cilium formation |
| Associated Diseases | Breast Cancer |
| Interactions | AND, APOPTOSIS, AUTOPHAGY, CANCER, EGF, ESR1 |
| KG Connections | 86 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!