concept

SMC1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMC1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

16Outgoing

0Incoming

0Experiments

0Debates

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💡 Concept Info

Name	SMC1A
Key Genes/Proteins	AKT, ANKRD11, BRD4, HDAC8, NIPBL, RAD21
Related Diseases	Als, breast cancer, colorectal cancer, Cornelia de Lange syndrome, developmental and epileptic encephalopathy

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SMC1A

gene · 847 words

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Pathway Diagram

graph TD
    SMC1A["SMC1A"]
    SMC1A -->|"causes"| Cornelia_de_Lange_syndrome["Cornelia de Lange syndrome"]
    SMC1A -->|"causes"| developmental_and_epileptic_en["developmental and epileptic encephalopathy"]
    SMC1A -->|"upregulates"| FOXM1["FOXM1"]
    SMC1A -->|"regulates"| STMN1["STMN1"]
    SMC1A -->|"activates"| AKT["AKT"]
    SMC1A -->|"causes"| breast_cancer["breast cancer"]
    SMC1A -->|"upregulates"| systemic_lupus_erythematosus["systemic lupus erythematosus"]

Outgoing (16)

Target	Relation	Type	Str
developmental and epileptic encephalopathy	causes	disease	0.90
Cornelia de Lange syndrome	causes	disease	0.90
breast cancer	causes	disease	0.80
colorectal cancer	associated_with	disease	0.80
intellectual disability	associated_with	phenotype	0.80
epilepsy	associated_with	disease	0.80
STMN1	regulates	protein	0.80
systemic lupus erythematosus	upregulates	disease	0.80
AKT	activates	protein	0.80
Als	associated_with	disease	0.65
ANKRD11	associated_with	gene	0.60
NIPBL	associated_with	gene	0.60
HDAC8	associated_with	gene	0.60
SMC3	associated_with	gene	0.60
BRD4	associated_with	gene	0.60
RAD21	associated_with	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SMC1A in their description or question text

No additional research found