Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAD21: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | RAD21 |
| Full Name | Cohesin Complex Component in Neurodegeneration |
| Chromosome | 8q24.11 |
| Protein Type | Cohesin Complex Subunit |
| Function | Loading: Cohesin is loaded onto DNA by the Scc2/4 complex during early S phase |
| Amino Acids | 581 aa |
| UniProt ID | Q9UQE5 |
| NCBI Gene ID | 11124 |
| Ensembl ID | ENSG00000164754 |
| OMIM | 606462 |
| GeneCards | RAD21 |
| Human Protein Atlas | RAD21 |
| Phosphorylation | By Polo-like kinases and Aurora B for proper chromosome behavior |
| Acetylation | By Eco1/Ctf7 during S phase for establishment of cohesion |
| Proteolytic cleavage | By separase (ESPL1) during anaphase to allow sister chromatid separation |
| Associated Diseases | Als |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
RAD21(["RAD21"])
Als["Als"]
SMC1A(["SMC1A"])
ANKRD11(["ANKRD11"])
NIPBL(["NIPBL"])
HDAC8(["HDAC8"])
SMC3(["SMC3"])
BRD4(["BRD4"])
neurodegeneration["neurodegeneration"]
RAD21 -->|"associated with"| Als
SMC1A -->|"associated with"| RAD21
ANKRD11 -->|"associated with"| RAD21
NIPBL -->|"associated with"| RAD21
HDAC8 -->|"associated with"| RAD21
SMC3 -->|"associated with"| RAD21
BRD4 -->|"associated with"| RAD21
RAD21 -->|"implicated in"| neurodegeneration
style RAD21 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| Als | associated_with | disease | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RAD21 in their description or question text
No additional research found