| Gene Symbol | HDAC8 |
| Aliases | HDAC8PROTEIN |
| Chromosome | Xq13.1 |
| Protein Type | Gene |
| Function | encodes a zinc-dependent class I histone deacetylase enzyme that plays a critical role in epigenetic regulation of gene expression. |
| Primary Expression | various tissues, with significant expression in the brain where it regulates chromatin structure and gene transcription essential for neuronal develop |
| Subcellular Localization | </strong></td><td>Nucleus</td></tr> |
| Molecular Weight | 42 kDa |
| Amino Acids | 377 aa |
| Exons | 14 |
| Pathways | NF-κB, NF-κB pathway |
| GeneCards | HDAC8 |
| Human Protein Atlas | HDAC8 |
| HDAC8 selective inhibitors | PCI-34051, FK228 (romidepsin) |
| Structure-based design | Developing more selective agents |
| Associated Diseases | Als, Alzheimer |
| Interactions | AND, APOPTOSIS, App, BAX, Bcl-2, BCL-2 |
| KG Connections | 143 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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