Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ankrd11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ANKRD11 |
| Full Name | Ankyrin Repeat Domain 11 |
| Chromosome | 16q24.3 |
| Protein Type | Gene |
| Function | ### Transcriptional Regulation |
| Primary Expression | the brain and has been implicated in neurodevelopment and neurodegeneration |
| Molecular Weight | 256 kDa |
| Amino Acids | 556 aa |
| Exons | 13 |
| GeneCards | ANKRD11 |
| Human Protein Atlas | ANKRD11 |
| Ankyrin repeats (N-terminal) | 8 ankyrin repeat motifs that mediate protein-protein interactions |
| Nuclear localization signals | Promote nuclear import |
| PEST sequences | Regulatory sequences affecting protein stability |
| Histone acetylation | ANKRD11 interacts with p300/CBP to enhance histone acetylation at target gene promoters |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["ANKRD11"]
N1["Als"]
N0 -->|"contributes to"| N1
N2["NIPBL"]
N0 -->|"associated with"| N2
N3["HDAC8"]
N0 -->|"associated with"| N3
N4["SMC3"]
N0 -->|"associated with"| N4
N5["BRD4"]
N0 -->|"contributes to"| N5
N6["RAD21"]
N0 -->|"associated with"| N6
N7["SMC1A"]
N7 -->|"associated with"| N0
N8["neurodegeneration"]
N0 -->|"implicated in"| N8
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 disease
class N2 gene
class N3 gene
class N4 gene
class N5 gene
class N6 gene
class N7 gene| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ANKRD11 | data_in | dataset_row | 0.00 |
| SMC1A | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ankrd11 in their description or question text
No additional research found