gene

PNOC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PNOC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

0Analyses

19Outgoing

11Incoming

0Experiments

0Debates

Summary

PNOC is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with ALS, Als, Diabetes. Connected to 19 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PNOC
Chromosome	8p21
Protein Type	Gene
Function	is a circuit and state modifier rather than a high-penetrance causative gene.
Molecular Weight	20 kDa
Amino Acids	17 aa
GeneCards	PNOC
Human Protein Atlas	PNOC
Associated Diseases	Als, Diabetes, Ms, Obesity
KG Connections	30 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PNOC Gene

gene · 719 words

→

PNOC Protein

protein · 993 words

→

Pathway Diagram

graph TD
    PNOC["PNOC"]
    Als{"Als"}
    PNOC -->|"associated with"| Als
    Obesity{"Obesity"}
    PNOC -->|"therapeutic target"| Obesity
    Ms{"Ms"}
    PNOC -->|"associated with"| Ms
    Diabetes{"Diabetes"}
    PNOC -->|"associated with"| Diabetes
    PNOC -->|"associated with"| Obesity
    ALS{"ALS"}
    PNOC -->|"associated with"| ALS
    TRPC6["TRPC6"]
    PNOC -->|"therapeutic target"| TRPC6
    HCRTR1["HCRTR1"]
    PNOC -->|"therapeutic target"| HCRTR1
    GENES["GENES"]
    PNOC -->|"therapeutic target"| GENES
    HCRTR2["HCRTR2"]
    PNOC -->|"therapeutic target"| HCRTR2
    PNOC -->|"associated with"| HCRTR2
    AND["AND"]
    PNOC -->|"associated with"| AND
    HCRTR2 -->|"therapeutic target"| PNOC
    HCRTR1 -->|"therapeutic target"| PNOC
    HCRTR1 -->|"associated with"| PNOC
    GENES -->|"associated with"| PNOC
    TRPC6 -->|"associated with"| PNOC
    style PNOC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (19)

Target	Relation	Type	Str
Ms	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Sleep Disorder	therapeutic_target	disease	0.65
Obesity	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Als	associated_with	disease	0.65
Obesity	therapeutic_target	disease	0.65
GENES	associated_with	gene	0.60
TRPC6	therapeutic_target	gene	0.60
AND	associated_with	gene	0.60
HCRTR1	therapeutic_target	gene	0.60
HCRTR2	therapeutic_target	gene	0.60
HCRTR2	associated_with	gene	0.60
TRPC6	associated_with	gene	0.60
HCRTR1	associated_with	gene	0.60
GENES	therapeutic_target	gene	0.60
TRPC6	targets	gene	0.60
App	associated_with	protein	0.60
OBESITY	associated_with	disease	0.50

Incoming (11)

Source	Relation	Type	Str
genes-pnoc	documents	wiki_page	1.00
genes-pnoc	describes	wiki_page	1.00
HCRTR1	targets	gene	0.60
HCRTR2	targets	gene	0.60
HCRTR1	therapeutic_target	gene	0.60
TRPC6	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
HCRTR1	associated_with	gene	0.60
TRPC6	associated_with	gene	0.60
HCRTR2	associated_with	gene	0.60
HCRTR2	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity