gene

LRRTM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRRTM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

0Analyses

22Outgoing

8Incoming

0Experiments

0Debates

Summary

LRRTM2 encodes a synaptic adhesion molecule essential for excitatory synapse development, binding to neurexins and inducing synaptic differentiation. Linked to autism, intellectual disability, and epilepsy.

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🧬 Gene Info

Gene Symbol	LRRTM2
Full Name	Leucine-Rich Repeat Transmembrane Neuronal 2
Chromosome	5q31.1
Function	is a synaptic adhesion molecule that plays a critical role in excitatory synapse development and function.
Primary Expression	the nervous system
Molecular Weight	62 kDa
Amino Acids	644 aa
Exons	3
UniProt ID	Q9H0Y5
NCBI Gene ID	25845
Ensembl ID	ENSG00000162881
OMIM	610868
GeneCards	LRRTM2
Human Protein Atlas	LRRTM2
2007	LRRTM family identified as neurexin ligands
Associated Diseases	Autism, Epilepsy
KG Connections	30 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: LRRTM2 — AlphaFold Q9H0Y5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LRRTM2 Gene

gene · 2255 words

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LRRTM2 Protein

protein · 551 words

→

Pathway Diagram

graph TD
    LRRTM2["LRRTM2"]
    Cancer{"Cancer"}
    LRRTM2 -->|"expressed_in"| Cancer
    Glioblastoma{"Glioblastoma"}
    LRRTM2 -->|"expressed_in"| Glioblastoma
    Als{"Als"}
    LRRTM2 -->|"expressed_in"| Als
    ALS{"ALS"}
    LRRTM2 -->|"expressed_in"| ALS
    GBM(["GBM"])
    GBM -->|"expressed_in"| LRRTM2
    OPRL1(["OPRL1"])
    OPRL1 -->|"associated_with"| LRRTM2
    GENES(["GENES"])
    GENES -->|"associated_with"| LRRTM2
    HCRTR1(["HCRTR1"])
    HCRTR1 -->|"expressed_in"| LRRTM2
    style LRRTM2 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (22)

Target	Relation	Type	Str
Cancer	expressed_in	disease	0.65
Glioblastoma	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Als	biomarker_for	disease	0.65
Cancer	biomarker_for	disease	0.65
Glioblastoma	biomarker_for	disease	0.65
OPRL1	associated_with	gene	0.60
Mapk	biomarker_for	pathway	0.60
MAPK	biomarker_for	gene	0.60
GLIOBLASTOMA	biomarker_for	gene	0.60
CPLX3	expressed_in	gene	0.60
HCRTR1	expressed_in	gene	0.60
Igf	expressed_in	protein	0.60
CPLX3	biomarker_for	gene	0.60
GBM	biomarker_for	gene	0.60
HCRTR1	biomarker_for	gene	0.60
MAPK	expressed_in	gene	0.60
OPRL1	co_expressed_with	gene	0.60
GLIOBLASTOMA	expressed_in	gene	0.60
Mapk	expressed_in	pathway	0.60
CANCER	expressed_in	gene	0.60

Incoming (8)

Source	Relation	Type	Str
GBM	expressed_in	gene	0.60
HCRTR1	expressed_in	gene	0.60
OPRL1	associated_with	gene	0.60
GENES	associated_with	gene	0.60
MAPK	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
GLIOBLASTOMA	expressed_in	gene	0.60
CPLX3	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LRRTM2 in their description or question text

No additional research found