Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CPLX3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CPLX3 |
| Full Name | Complexin-3 |
| Chromosome | 5q23.1 |
| Function | is a neuronal protein that regulates synaptic vesicle fusion by binding to the SNARE complex. |
| Primary Expression | photoreceptor cells, bipolar cells, and various brain regions including the hippocampus and cortex |
| Amino Acids | 156 aa |
| UniProt ID | Q9BQY1 |
| NCBI Gene ID | 81571 |
| Ensembl ID | ENSG00000177468 |
| OMIM | 618251 |
| GeneCards | CPLX3 |
| Human Protein Atlas | CPLX3 |
| Associated Diseases | vision |
| Interactions | AND, GBM, GENES, HCRTR1, Igf |
| KG Connections | 38 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CPLX3["CPLX3"]
transmitter_release["transmitter release"]
CPLX3 -->|"regulates"| transmitter_release
SNARE_complex["SNARE complex"]
CPLX3 -->|"regulates"| SNARE_complex
synaptic_vesicle_fusion["synaptic vesicle fusion"]
CPLX3 -->|"regulates"| synaptic_vesicle_fusion
photoreceptor_ribbon_synapses["photoreceptor ribbon synapses"]
CPLX3 -->|"participates in"| photoreceptor_ribbon_synapses
photoreceptor_ribbon_synaptic_function["photoreceptor ribbon synaptic function"]
CPLX3 -->|"participates in"| photoreceptor_ribbon_synaptic_function
vision["vision"]
CPLX3 -->|"associated with"| vision
neurodegeneration["neurodegeneration"]
CPLX3 -->|"implicated in"| neurodegeneration
style CPLX3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| transmitter release | regulates | biological_process | 0.90 |
| SNARE complex | regulates | entity | 0.80 |
| synaptic vesicle fusion | regulates | biological_process | 0.80 |
| photoreceptor ribbon synapses | participates_in | biological_process | 0.80 |
| photoreceptor ribbon synaptic function | participates_in | biological_process | 0.80 |
| vision | associated_with | phenotype | 0.70 |
| Als | inhibits | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Cancer | biomarker_for | disease | 0.65 |
| Glioblastoma | biomarker_for | disease | 0.65 |
| Glioblastoma | expressed_in | disease | 0.65 |
| ALS | inhibits | disease | 0.65 |
| GBM | activates | gene | 0.60 |
| HCRTR1 | activates | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| OPRL1 | expressed_in | gene | 0.60 |
| Igf | inhibits | protein | 0.60 |
| LRRTM2 | expressed_in | gene | 0.60 |
| HCRTR1 | inhibits | gene | 0.60 |
| GBM | inhibits | gene | 0.60 |
| glioblastoma | activates | disease | 0.60 |
| GLIOBLASTOMA | biomarker_for | gene | 0.60 |
| MAPK | expressed_in | gene | 0.60 |
| Mapk | biomarker_for | pathway | 0.60 |
| GLIOBLASTOMA | expressed_in | gene | 0.60 |
| Mapk | expressed_in | pathway | 0.60 |
| OPRL1 | biomarker_for | gene | 0.60 |
| MAPK | biomarker_for | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CPLX3 in their description or question text
No additional research found