| Gene Symbol | HCRT1 |
| Full Name | HCRTR1 |
| Protein Type | Gpcr |
| Target Class | Gpcr |
| Function | Small molecule antagonist blocking orexin receptor signaling |
| Mechanism of Action | Small molecule antagonist blocking orexin receptor signaling |
| Druggability | Medium (0.60) |
| Clinical Stage | Approved |
| Amino Acids | 33 aa |
| Pathways | Circadian rhythm / glymphatic clearance, NF-κB signaling, Sleep-Wake Transition |
| UniProt ID | A6NMV7 |
| GeneCards | HCRT1 |
| Human Protein Atlas | HCRT1 |
| Orexin-A (Hypocretin-1) | A 33-amino acid peptide with two disulfide bonds[@sakurai2007] |
| Orexin-B (Hypocretin-2) | A 28-amino acid linear peptide[@sakurai2007] |
| Associated Diseases | Addiction, Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | Propofol, suvorexant |
| Interactions | 5-HT1AR, ACE, ADRA1A, ADRA1B, AQP4, ASTROCYTE |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Daytime orexin tone preserves synaptic plasticity |
| KG Connections | 321 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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