gene

GRIN3B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRIN3B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

0Hypotheses

0Analyses

29Outgoing

19Incoming

0Experiments

0Debates

Summary

GRIN3B Gene — NMDA Receptor Subunit 3B

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🧬 Gene Info

Gene Symbol	GRIN3B
Full Name	GRIN3B — NMDA Receptor Subunit 3B
Aliases	NMDA Receptor Subunit 3B
Chromosome	19q13.31
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	the peripheral and central nervous systems and forms functional receptors with GRIN1 and GRIN2 subunits
Exons	22
Pathways	Wnt
GeneCards	GRIN3B
Human Protein Atlas	GRIN3B
Associated Diseases	neurodegeneration
Interactions	ASTROCYTE, Cytokine, CYTOKINES, GENES, IL13, MYO7A
KG Connections	48 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GRIN3B Gene — NMDA Receptor Subunit 3B

gene · 577 words

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Pathway Diagram

graph TD
    GRIN3B["GRIN3B"]
    Als["Als"]
    TNFRSF1B["TNFRSF1B"]
    GABA["GABA"]
    TNFRSF13C["TNFRSF13C"]
    HCRTR1["HCRTR1"]
    CYTOKINES["CYTOKINES"]
    Wnt["Wnt"]
    Microglia["Microglia"]
    Astrocyte["Astrocyte"]
    CHRM4["CHRM4"]
    MYO7A["MYO7A"]
    GRM2["GRM2"]
    WNT1["WNT1"]
    ASTROCYTE["ASTROCYTE"]
    CRH["CRH"]
    WNT["WNT"]
    ADRA2B["ADRA2B"]
    IL13["IL13"]
    CHRNE["CHRNE"]
    WNT11["WNT11"]
    GRIN3B -->|"activates"| Als
    GRIN3B -->|"activates"| TNFRSF1B
    GRIN3B -->|"expressed in"| GABA
    GRIN3B -->|"activates"| TNFRSF13C
    GRIN3B -->|"expressed in"| HCRTR1
    GRIN3B -->|"activates"| CYTOKINES
    GRIN3B -->|"activates"| Wnt
    GRIN3B -->|"activates"| Microglia
    GRIN3B -->|"activates"| Astrocyte
    CHRM4 -->|"expressed in"| GRIN3B
    MYO7A -->|"activates"| GRIN3B
    GRM2 -->|"expressed in"| GRIN3B
    WNT1 -->|"activates"| GRIN3B
    ASTROCYTE -->|"activates"| GRIN3B
    CRH -->|"expressed in"| GRIN3B
    WNT -->|"activates"| GRIN3B
    ADRA2B -->|"expressed in"| GRIN3B
    IL13 -->|"activates"| GRIN3B
    CHRNE -->|"expressed in"| GRIN3B
    WNT11 -->|"activates"| GRIN3B
    style GRIN3B fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (29)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:GRIN3B	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
ALS	activates	disease	0.65
Als	activates	disease	0.65
GABA	expressed_in	gene	0.60
CYTOKINES	activates	gene	0.60
Wnt	activates	pathway	0.60
Microglia	activates	cell_type	0.60
Astrocyte	activates	cell_type	0.60
GENES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
Cytokine	activates	protein	0.60
WNT1	activates	gene	0.60
Rb	expressed_in	protein	0.60
TNFRSF1B	activates	gene	0.60
TNFRSF13C	activates	gene	0.60
HCRTR1	expressed_in	gene	0.60
CRH	expressed_in	gene	0.60
WNT11	activates	gene	0.60
MYO7A	activates	gene	0.60
CHRM4	expressed_in	gene	0.60
ADRA2B	expressed_in	gene	0.60
IL13	activates	gene	0.60
CHRNE	expressed_in	gene	0.60
GRM2	expressed_in	gene	0.60
Brainstem	expressed_in	brain_region	0.55
Microglia	expressed_in	cell_type	0.55
Astrocyte	expressed_in	cell_type	0.55
GLUTAMATE	expressed_in	concept	0.50

Incoming (19)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:GRIN3B	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
TNFRSF13C	activates	gene	0.60
ADRA2B	expressed_in	gene	0.60
IL13	activates	gene	0.60
CHRNE	expressed_in	gene	0.60
WNT11	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
WNT	activates	gene	0.60
TNFRSF1B	activates	gene	0.60
CHRM4	expressed_in	gene	0.60
MYO7A	activates	gene	0.60
GRM2	expressed_in	gene	0.60
WNT1	activates	gene	0.60
CRH	expressed_in	gene	0.60
CYTOKINES	activates	gene	0.60
GABA	expressed_in	gene	0.50
acetylcholine	expressed_in	disease	0.50
HCRTR1	expressed_in	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GRIN3B in their description or question text

No additional research found