gene

WNT11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WNT11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections

0Hypotheses

0Analyses

26Outgoing

14Incoming

0Experiments

0Debates

Summary

Wnt Family Member 11 - secreted signaling protein primarily activating non-canonical Wnt/PCP and Wnt/Calcium pathways, regulating cell polarity and neuronal development

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🧬 Gene Info

Gene Symbol	WNT11
Aliases	Wnt Family Member 11
Function	Like all Wnt proteins, WNT11 contains several structural features essential for its function
Amino Acids	354 aa
Pathways	WNT, Wnt, Wnt signaling, Wnt pathway
Ensembl ID	ENSG00000169718
GeneCards	WNT11
Human Protein Atlas	WNT11
Wnt domain (residues 51-354)	The conserved signaling domain containing multiple cysteine residues
Conserved cysteine pattern	Ten conserved cysteine residues form disulfide bonds that stabilize the protein structure
Lipid modification site	Palmitoylation at a conserved cysteine is required for proper secretion and activity
Convergent extension	Cell movements during gastrulation and neural tube closure
Tissue patterning	Establishing planar polarity in epithelial tissues
Axonal guidance	Directional growth of axons during development
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	ADRA2B, ASTROCYTE, CHRM4, CHRNE, CRH, CYTOKINES
KG Connections	40 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

WNT11 Gene

gene · 1577 words

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Pathway Diagram

graph TD
    WNT11["WNT11"]
    Als["Als"]
    GRIN3B["GRIN3B"]
    TNFRSF1B["TNFRSF1B"]
    GABA["GABA"]
    TNFRSF13C["TNFRSF13C"]
    HCRTR1["HCRTR1"]
    CYTOKINES["CYTOKINES"]
    Wnt["Wnt"]
    Microglia["Microglia"]
    Astrocyte["Astrocyte"]
    CHRM4["CHRM4"]
    MYO7A["MYO7A"]
    GRM2["GRM2"]
    WNT1["WNT1"]
    ASTROCYTE["ASTROCYTE"]
    CRH["CRH"]
    WNT["WNT"]
    ADRA2B["ADRA2B"]
    IL13["IL13"]
    CHRNE["CHRNE"]
    WNT11 -->|"activates"| Als
    WNT11 -->|"activates"| GRIN3B
    WNT11 -->|"activates"| TNFRSF1B
    WNT11 -->|"activates"| GABA
    WNT11 -->|"activates"| TNFRSF13C
    WNT11 -->|"activates"| HCRTR1
    WNT11 -->|"activates"| CYTOKINES
    WNT11 -->|"activates"| Wnt
    WNT11 -->|"activates"| Microglia
    WNT11 -->|"activates"| Astrocyte
    CHRM4 -->|"activates"| WNT11
    MYO7A -->|"activates"| WNT11
    GRM2 -->|"activates"| WNT11
    WNT1 -->|"activates"| WNT11
    ASTROCYTE -->|"activates"| WNT11
    CRH -->|"activates"| WNT11
    WNT -->|"activates"| WNT11
    ADRA2B -->|"activates"| WNT11
    IL13 -->|"activates"| WNT11
    CHRNE -->|"activates"| WNT11
    style WNT11 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (26)

Target	Relation	Type	Str
ALS	activates	disease	0.65
Als	activates	disease	0.65
GABA	activates	gene	0.60
CYTOKINES	activates	gene	0.60
Wnt	activates	pathway	0.60
Microglia	activates	cell_type	0.60
Astrocyte	activates	cell_type	0.60
TNFRSF1B	activates	gene	0.60
TNFRSF13C	activates	gene	0.60
HCRTR1	activates	gene	0.60
MYO7A	activates	gene	0.60
CHRM4	activates	gene	0.60
ADRA2B	activates	gene	0.60
IL13	activates	gene	0.60
CHRNE	activates	gene	0.60
GRM2	activates	gene	0.60
GRIN3B	activates	gene	0.60
CRH	activates	gene	0.60
Rb	activates	protein	0.60
GENES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
Microglia	expressed_in	cell_type	0.55
Brainstem	expressed_in	brain_region	0.55
Astrocyte	expressed_in	cell_type	0.55
WNT1	activates	gene	0.50
WNT SIGNALING	activates	concept	0.50

Incoming (14)

Source	Relation	Type	Str
CHRM4	activates	gene	0.60
MYO7A	activates	gene	0.60
GRM2	activates	gene	0.60
WNT1	activates	gene	0.60
CRH	activates	gene	0.60
ADRA2B	activates	gene	0.60
IL13	activates	gene	0.60
CHRNE	activates	gene	0.60
TNFRSF1B	activates	gene	0.60
GRIN3B	activates	gene	0.60
HCRTR1	activates	gene	0.60
CYTOKINES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
WNT	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WNT11 in their description or question text

No additional research found