gene

TNFRSF13C

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFRSF13C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

66Connections

0Hypotheses

0Analyses

42Outgoing

24Incoming

0Experiments

0Debates

Summary

BAFFR Gene (TNFRSF13C)

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	BAFFR
Full Name	B Cell Activating Factor Receptor
Chromosome	22q12.1
Protein Type	Type I transmembrane receptor
Function	Mice lacking BAFFR (Tnfrsf13c knockout) or BAFF have severely reduced mature B cell numbers - B cell maturation: BAFFR is essential for the transition of transitional B cells to mature B cells in the
Molecular Weight	~19.2 kDa
Amino Acids	184 aa
Exons	5
UniProt ID	Q9Y239
GeneCards	BAFFR
Human Protein Atlas	BAFFR
Associated Diseases	Ataxia, disease, Neurodegeneration, Spinocerebellar Ataxia
Interactions	ADRA2B, AND, ASTROCYTE, CHRM4, CHRNE, CRH
KG Connections	66 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TNFRSF13C — AlphaFold Q9Y239 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

BAFFR Gene (TNFRSF13C)

gene · 1846 words

→

Pathway Diagram

graph TD
    TNFRSF13C["TNFRSF13C"]
    Sj_gren_s_Syndrome["Sjögren's Syndrome"]
    Als["Als"]
    Neurodegeneration["Neurodegeneration"]
    HCRTR1["HCRTR1"]
    CYTOKINES["CYTOKINES"]
    Wnt["Wnt"]
    Microglia["Microglia"]
    Astrocyte["Astrocyte"]
    SCA3["SCA3"]
    Oligodendrocyte["Oligodendrocyte"]
    Neuron["Neuron"]
    CHRM4["CHRM4"]
    MYO7A["MYO7A"]
    GRM2["GRM2"]
    WNT1["WNT1"]
    ASTROCYTE["ASTROCYTE"]
    CRH["CRH"]
    WNT["WNT"]
    ADRA2B["ADRA2B"]
    IL13["IL13"]
    TNFRSF13C -->|"involved in"| Sj_gren_s_Syndrome
    TNFRSF13C -->|"activates"| Als
    TNFRSF13C -.-|"associated"| Neurodegeneration
    TNFRSF13C -->|"activates"| HCRTR1
    TNFRSF13C -->|"activates"| CYTOKINES
    TNFRSF13C -->|"activates"| Wnt
    TNFRSF13C -->|"activates"| Microglia
    TNFRSF13C -->|"activates"| Astrocyte
    TNFRSF13C -.-|"associated"| SCA3
    TNFRSF13C -.-|"associated"| Oligodendrocyte
    TNFRSF13C -.-|"associated"| Neuron
    CHRM4 -->|"activates"| TNFRSF13C
    MYO7A -->|"activates"| TNFRSF13C
    GRM2 -->|"activates"| TNFRSF13C
    WNT1 -->|"activates"| TNFRSF13C
    ASTROCYTE -->|"activates"| TNFRSF13C
    CRH -->|"activates"| TNFRSF13C
    WNT -->|"activates"| TNFRSF13C
    ADRA2B -->|"activates"| TNFRSF13C
    IL13 -->|"activates"| TNFRSF13C
    style TNFRSF13C fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (42)

Target	Relation	Type	Str
Als	activates	disease	0.65
ALS	activates	disease	0.65
Ataxia	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Neurodegeneration	stabilizes	disease	0.65
Neuron	stabilizes	cell_type	0.60
Oligodendrocyte	associated_with	cell_type	0.60
Neuron	associated_with	cell_type	0.60
AND	associated_with	gene	0.60
Oligodendrocyte	encodes	cell_type	0.60
ATXN3	associated_with	gene	0.60
CHRM4	activates	gene	0.60
MYO7A	activates	gene	0.60
ADRA2B	activates	gene	0.60
GRM2	activates	gene	0.60
SCA3	encodes	gene	0.60
CRH	activates	gene	0.60
CHRNE	activates	gene	0.60
GRIN3B	activates	gene	0.60
TNFRSF1B	activates	gene	0.60
WNT1	activates	gene	0.60
Rb	activates	protein	0.60
Rb	associated_with	protein	0.60
CYTOKINES	activates	gene	0.60
HCRTR1	activates	gene	0.60
SCA3	associated_with	gene	0.60
Wnt	activates	pathway	0.60
Microglia	activates	cell_type	0.60
Astrocyte	activates	cell_type	0.60
GABA	activates	gene	0.60
Cytokine	activates	protein	0.60
Oligodendrocyte	expressed_in	cell_type	0.55
White Matter	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
Ca3	expressed_in	brain_region	0.55
Microglia	expressed_in	cell_type	0.55
Brainstem	expressed_in	brain_region	0.55
Astrocyte	expressed_in	cell_type	0.55
disease	associated_with	disease	0.50
BRAINSTEM	associated_with	concept	0.50
CYTOKINE	activates	concept	0.50

Incoming (24)

Source	Relation	Type	Str
CHRM4	activates	gene	0.60
MYO7A	activates	gene	0.60
GRM2	activates	gene	0.60
WNT1	activates	gene	0.60
CRH	activates	gene	0.60
ADRA2B	activates	gene	0.60
IL13	activates	gene	0.60
CHRNE	activates	gene	0.60
WNT11	activates	gene	0.60
GRIN3B	activates	gene	0.60
TNFRSF1B	activates	gene	0.60
ATXN3	associated_with	gene	0.60
HCRTR1	activates	gene	0.60
GAIN	associated_with	gene	0.60
ATXN3	stabilizes	gene	0.60
CYTOKINES	activates	gene	0.60
AND	activates	gene	0.60
GENES	activates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
OLIGODENDROCYTE	associated_with	gene	0.60
ASTROCYTE	activates	gene	0.60
WNT	activates	gene	0.60
GABA	activates	gene	0.60
sca3	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TNFRSF13C in their description or question text

No additional research found