gene

MBNL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MBNL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

0Hypotheses

0Analyses

14Outgoing

13Incoming

0Experiments

0Debates

Summary

mbnl1

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🧬 Gene Info

Gene Symbol	MBNL1
Function	MBNL1 is a zinc finger RNA-binding protein that regulates alternative splicing, RNA localization, and RNA stability through binding to specific sequence motifs[@charizanis2012]:
Primary Expression	White Matter
Pathways	insulin signaling
Ensembl ID	ENSG00000138700
GeneCards	MBNL1
Human Protein Atlas	MBNL1
Associated Diseases	Huntington's disease
Interactions	DMPK, MBNL2, Proteins, RNA
KG Connections	27 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

mbnl1

gene · 2787 words

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Pathway Diagram

graph TD
    MBNL1["MBNL1"]
    MBNL1 -->|"interacts"| MBNL2["MBNL2"]
    MBNL1 -->|"interacts"| RNA["RNA"]
    MBNL1 -->|"interacts"| DMPK["DMPK"]
    MBNL1 -->|"inhibits"| AND["AND"]
    MBNL1 -->|"expressed in"| White_Matter["White Matter"]
    DMPK -->|"interacts"| MBNL1
    BDNF["BDNF"] -->|"regulates"| MBNL1
    MBNL2 -->|"interacts"| MBNL1
    RNA -->|"interacts"| MBNL1

Outgoing (14)

Target	Relation	Type	Str
BDNF	regulates_retrograde_signaling_of	gene	0.80
RNA	interacts_with	gene	0.60
DMPK	inhibits	gene	0.60
RNA	inhibits	gene	0.60
MBNL2	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
MBNL2	interacts_with	gene	0.60
DMPK	interacts_with	gene	0.60
Huntington's disease	causes	disease	0.55
neurons	expressed_in	cell_type	0.55
RNA	biomarker_for	gene	0.55
White Matter	expressed_in	brain_region	0.55
insulin signaling	participates_in	pathway	0.55
Proteins	interacts_with	protein	0.50

Incoming (13)

Source	Relation	Type	Str
RNA	interacts_with	gene	0.60
DMPK	interacts_with	gene	0.60
CLCN1	associated_with	gene	0.60
BDNF	regulates	gene	0.60
MBNL2	interacts_with	gene	0.60
DMPK	expressed_in	gene	0.60
INSR	causes	gene	0.55
CACNA1G	causes	gene	0.55
GRIN1	causes	gene	0.55
HTT	causes	gene	0.55
CLCN1	causes	gene	0.55
DMPK	causes	gene	0.55
BDNF	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MBNL1 in their description or question text

No additional research found