gene

HIP1R

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HIP1R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

2Outgoing

9Incoming

0Experiments

0Debates

Summary

HIP1R encodes a critical protein involved in clathrin-mediated endocytosis, actin cytoskeleton dynamics, and cellular trafficking. Implicated in Huntington's disease, Alzheimer's disease, and Parkinson's disease through its interactions with huntingtin and role in synaptic function.

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🧬 Gene Info

Gene Symbol	HIP1R
Aliases	SLAIN2, B murine sarcoma virus CT10
Chromosome	22q13.31
Protein Type	Clathrin coat component, Actin-binding protein
Function	encodes a critical protein involved in clathrin-mediated endocytosis, actin cytoskeleton organization, and cellular trafficking.
Primary Expression	the brain, particularly in neurons of the cortex, hippocampus, and cerebellum, where it performs essential roles in synaptic vesicle trafficking, rece
Molecular Weight	116 kDa
Amino Acids	1031 aa
Ensembl ID	ENSG00000128284
GeneCards	HIP1R
Human Protein Atlas	HIP1R
Associated Diseases	Als
KG Connections	11 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HIP1R (Huntingtin Interacting Protein 1-Related)

gene · 2170 words

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Pathway Diagram

graph TD
    HIP1R["HIP1R"]
    Als{"Als"}
    HIP1R -->|"associated with"| Als
    Cardiac{"Cardiac"}
    HIP1R -->|"regulates"| Cardiac
    neurodegeneration["neurodegeneration"]
    HIP1R -->|"implicated in"| neurodegeneration
    RYR2["RYR2"]
    RYR2 -->|"regulates"| HIP1R
    SCN1A["SCN1A"]
    SCN1A -->|"regulates"| HIP1R
    ROBO1["ROBO1"]
    ROBO1 -->|"associated with"| HIP1R
    GAD2["GAD2"]
    GAD2 -->|"regulates"| HIP1R
    PIK3CB["PIK3CB"]
    PIK3CB -->|"regulates"| HIP1R
    NOS1["NOS1"]
    NOS1 -->|"regulates"| HIP1R
    CFTR["CFTR"]
    CFTR -->|"regulates"| HIP1R
    EPHB4["EPHB4"]
    EPHB4 -->|"associated with"| HIP1R
    MMP2["MMP2"]
    MMP2 -->|"associated with"| HIP1R
    style HIP1R fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (2)

Target	Relation	Type	Str
Als	associated_with	disease	0.65
Cardiac	regulates	disease	0.65

Incoming (9)

Source	Relation	Type	Str
RYR2	regulates	gene	0.60
SCN1A	regulates	gene	0.60
ROBO1	associated_with	gene	0.60
GAD2	regulates	gene	0.60
PIK3CB	regulates	gene	0.60
NOS1	regulates	gene	0.60
CFTR	regulates	gene	0.60
EPHB4	associated_with	gene	0.60
MMP2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HIP1R in their description or question text

No additional research found