gene

TRPC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

34Connections

0Hypotheses

0Analyses

16Outgoing

18Incoming

0Experiments

0Debates

Summary

TRPC1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, implicated in. Associated with Hypertension. Connected to 11 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TRPC1
Full Name	Transient Receptor Potential Cation Channel Subfamily C Member 1
Chromosome	3q23
Protein Type	Channel
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Ubiquitous - Brain, Heart, Skeletal muscle, Endothelium
Molecular Weight	90 kDa
Amino Acids	793 aa
Exons	13
UniProt ID	P48995
NCBI Gene ID	7220
Ensembl ID	ENSG00000113615
OMIM	602409
GeneCards	TRPC1
Human Protein Atlas	TRPC1
Associated Diseases	Alzheimer's Disease, Parkinson's Disease, Stroke
Interactions	AND, APOE4, FOXO, FSP1, Fus, GENES
KG Connections	34 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TRPC1 — AlphaFold P48995 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TRPC1 Gene

gene · 699 words

→

TRPC1 Protein

protein · 607 words

→

Pathway Diagram

graph TD
    TRPC1["TRPC1"]
    Hypertension{"Hypertension"}
    TRPC1 -->|"activates"| Hypertension
    TRPC1 -->|"regulates"| Hypertension
    TRPV4["TRPV4"]
    TRPC1 -->|"activates"| TRPV4
    FSP1["FSP1"]
    TRPC1 -->|"activates"| FSP1
    GENES["GENES"]
    TRPC1 -->|"activates"| GENES
    PIEZO1["PIEZO1"]
    TRPC1 -->|"activates"| PIEZO1
    KCNK2["KCNK2"]
    TRPC1 -->|"activates"| KCNK2
    AND["AND"]
    TRPC1 -->|"activates"| AND
    neurodegeneration["neurodegeneration"]
    TRPC1 -->|"implicated in"| neurodegeneration
    PIEZO1 -->|"activates"| TRPC1
    KCNK2 -->|"activates"| TRPC1
    FSP1 -->|"activates"| TRPC1
    style TRPC1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (16)

Target	Relation	Type	Str
Hypertension	activates	disease	0.65
Hypertension	regulates	disease	0.65
neuroinflammation	activates	disease	0.60
GENES	activates	gene	0.60
Fus	activates	protein	0.60
Rb	activates	protein	0.60
PIEZO1	activates	gene	0.60
KCNK2	activates	gene	0.60
PIEZO	activates	gene	0.60
TREK-1	activates	gene	0.60
AND	activates	gene	0.60
TRPV4	activates	gene	0.60
FSP1	activates	gene	0.60
TRPV4	inhibits	entity	0.60
TRPV4	co_discussed	gene	0.50
WAS	co_discussed	protein	0.50

Incoming (18)

Source	Relation	Type	Str
GENES	activates	gene	0.60
FOXO	activates	gene	0.60
FSP1	inhibits	entity	0.60
KCNK2	inhibits	entity	0.60
PIEZO1	inhibits	entity	0.60
APOE4	activates	gene	0.60
FSP1	activates	gene	0.60
TRPV4	activates	gene	0.60
TREK-1	activates	gene	0.60
AND	activates	gene	0.60
PIEZO	activates	gene	0.60
PIEZO1	activates	gene	0.60
KCNK2	activates	gene	0.60
GENES	co_discussed	gene	0.50
KCNK2	expressed_in	gene	0.50
PIEZO1	co_discussed	gene	0.50
FSP1	co_discussed	gene	0.50
TREK-1	co_discussed	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRPC1 in their description or question text

No additional research found