concept

FERROPTOSIS PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FERROPTOSIS PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

81Connections

0Hypotheses

0Analyses

17Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	FERROPTOSIS PATHWAY
Key Genes/Proteins	ACSL4, GPX4, HMGB1, NLRP3, NRF2
Related Diseases	APOPTOSIS, CANCER, OXIDATIVE STRESS, PARKINSON'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Ferroptosis Pathway in Neurodegeneration

mechanism · 2523 words

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Pathway Diagram

graph TD
    FERROPTOSIS_PATHWAY["FERROPTOSIS PATHWAY"]
    FERROPTOSIS_PATHWAY -->|"regulates"| T_Cell["T Cell"]
    FERROPTOSIS_PATHWAY -->|"activates"| Epithelial["Epithelial"]
    FERROPTOSIS_PATHWAY -->|"regulates"| Macrophage["Macrophage"]
    FERROPTOSIS_PATHWAY -->|"inhibits"| Fibroblast["Fibroblast"]
    FERROPTOSIS_PATHWAY -->|"inhibits"| Cardiomyocyte["Cardiomyocyte"]
    FERROPTOSIS_PATHWAY -->|"expressed in"| Pericyte["Pericyte"]
    FERROPTOSIS_PATHWAY -->|"expressed in"| Endothelial["Endothelial"]
    GPX4["GPX4"] -->|"regulates"| FERROPTOSIS_PATHWAY
    ALOX12["ALOX12"] -->|"inhibits"| FERROPTOSIS_PATHWAY
    P53["P53"] -->|"inhibits"| FERROPTOSIS_PATHWAY
    FERROPTOSIS["FERROPTOSIS"] -->|"inhibits"| FERROPTOSIS_PATHWAY
    ACSL4["ACSL4"] -->|"inhibits"| FERROPTOSIS_PATHWAY
    MTDNA["MTDNA"] -->|"activates"| FERROPTOSIS_PATHWAY
    ATG["ATG"] -->|"activates"| FERROPTOSIS_PATHWAY

Outgoing (17)

Target	Relation	Type	Str
CANCER	inhibits	disease	0.65
Epithelial	activates	cell_type	0.50
Fibroblast	inhibits	cell_type	0.50
Cardiomyocyte	inhibits	cell_type	0.50
Macrophage	regulates	cell_type	0.50
Epithelial	associated_with	cell_type	0.50
GPX4	associated_with	gene	0.50
NRF2	associated_with	gene	0.50
T Cell	regulates	cell_type	0.50
Pericyte	expressed_in	cell_type	0.50
Endothelial	expressed_in	cell_type	0.50
OXIDATIVE STRESS	associated_with	phenotype	0.45
NEURON	associated_with	cell_type	0.45
ACSL4	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
NLRP3	associated_with	gene	0.45
HMGB1	associated_with	gene	0.45

Incoming (64)

Source	Relation	Type	Str
NRF2	regulates	gene	0.65
FERROPTOSIS	therapeutic_target	gene	0.60
GPX4	regulates	gene	0.60
ALOX12	inhibits	gene	0.60
ACSL4	inhibits	gene	0.60
GPX4	activates	gene	0.60
POLG	activates	gene	0.60
NCOA4	activates	gene	0.60
ATM	activates	gene	0.60
SLC7A11	activates	gene	0.60
FANCD2	activates	gene	0.60
TFAM	activates	gene	0.60
CGAS	activates	gene	0.60
GSTP1	activates	gene	0.60
TGM2	activates	gene	0.60
CD36	regulates	gene	0.60
SCD1	associated_with	gene	0.60
ATF4	therapeutic_target	gene	0.60
FGF21	therapeutic_target	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
MITOPHAGY	associated_with	gene	0.60
FERROPTOSIS	regulates	gene	0.60
RNA	associated_with	gene	0.60
FERROPTOSIS	expressed_in	gene	0.60
PERICYTE	expressed_in	gene	0.60
AMYLOID	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
P53	inhibits	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
MTDNA	activates	gene	0.60
ATG	activates	gene	0.60
ALOX	activates	gene	0.60
DNA	activates	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ROS	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
Ferroptosis	activates	disease	0.55
Ferritin	therapeutic_target	protein	0.55
Insulin Receptor	expressed_in	protein	0.55
Rb	regulates	protein	0.55
Rb	activates	protein	0.55
Ras	activates	protein	0.55
App	activates	protein	0.55
Ferroptosis	expressed_in	disease	0.55
Alzheimer	expressed_in	disease	0.55
Insulin	expressed_in	protein	0.55
Raf	regulates	protein	0.55
Ferroptosis	regulates	disease	0.55
Fibrosis	regulates	disease	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FERROPTOSIS PATHWAY in their description or question text

No additional research found