concept

ERBB3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ERBB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

144Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ERBB3 is a concept in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with Aging, Als, Cancer. Connected to 94 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ERBB3
Key Genes/Proteins	ACAT1, AKT, AND, APOPTOSIS, App, APP
Related Diseases	Aging, Als
Related Pathways	Akt, Apoptosis, apoptosis pathway, Autophagy, autophagy pathway

Wiki Pages (1)

Knowledge base pages for this entity

ERBB3 (HER3) Protein

protein · 581 words

→

Pathway Diagram

graph TD
    ERBB3["ERBB3"]
    ERBB3 -->|"inhibits"| CHONDROCYTE_APOPTOSIS["CHONDROCYTE APOPTOSIS"]
    ERBB3 -->|"activates"| CHONDROCYTE_AUTOPHAGY["CHONDROCYTE AUTOPHAGY"]
    ERBB3 -->|"regulates"| Ms["Ms"]
    ERBB3 -->|"activates"| Cancer["Cancer"]
    ERBB3 -->|"activates"| Tumor["Tumor"]
    ERBB3 -->|"interacts"| Als["Als"]
    __HYDROXYBUTYRATE["Beta-HYDROXYBUTYRATE"] -->|"activates"| ERBB3
    ErbB2["ErbB2"] -->|"interacts"| ERBB3
    BACE1["BACE1"] -->|"target for"| ERBB3
    ST6GAL1["ST6GAL1"] -->|"regulates"| ERBB3
    APP["APP"] -->|"target for"| ERBB3
    MAX["MAX"] -->|"regulates"| ERBB3
    EGFR["EGFR"] -->|"target for"| ERBB3
    FUT8["FUT8"] -->|"regulates"| ERBB3
    ERK["ERK"] -->|"activates"| ERBB3
    GAIN["GAIN"] -->|"activates"| ERBB3

Outgoing (94)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ERBB3	data_in	dataset_row	0.00
CHONDROCYTE AUTOPHAGY	activates	gene	0.80
CHONDROCYTE APOPTOSIS	inhibits	gene	0.80
oxidative stress response	participates_in	pathway	0.80
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Cancer	regulates	disease	0.65
Neuropathy	associated_with	disease	0.65
Als	associated_with	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Cancer	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Aging	treats	disease	0.65
Inflammation	treats	disease	0.65
Als	activates	disease	0.65
Osteoarthritis	activates	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	regulates	disease	0.65
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
ERBB2	associated_with	gene	0.60
SRPK1	targets	gene	0.60
SRC	interacts_with	gene	0.60
autophagy pathway	participates_in	pathway	0.60
HER2	activates	gene	0.60
Tgf-Β	therapeutic_target	pathway	0.60
TP53	activates	gene	0.60
MEIS1	activates	gene	0.60
ELF3	activates	gene	0.60
Akt	activates	pathway	0.60
Pi3K	activates	pathway	0.60
Mapk	activates	pathway	0.60
FUT8	associated_with	gene	0.60
MAX	associated_with	gene	0.60
ST6GAL1	associated_with	gene	0.60
NRG1	inhibits	gene	0.60
Tgf-Β	contributes_to	pathway	0.60
EGFR	regulates	gene	0.60
AND	contributes_to	gene	0.60
BACE1	therapeutic_target	gene	0.60
Epithelial	therapeutic_target	cell_type	0.60
P53	activates	protein	0.60
KRAS	associated_with	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
EGF	regulates	gene	0.60
ERK	activates	gene	0.60
GAIN	activates	gene	0.60
PHGDH	activates	gene	0.60

Incoming (50)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ERBB3	data_in	dataset_row	0.00
ErbB2	interacts_with	gene	0.90
Β-HYDROXYBUTYRATE	activates	gene	0.90
ERBB2	interacts_with	protein	0.90
NDUFAF3	associated_with	gene	0.80
gain_of_function	associated_with	phenotype	0.64
CLDN4	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
CDH1	regulates	gene	0.60
ELF3	activates	gene	0.60
PDGFRA	inhibits	gene	0.60
TP53	activates	gene	0.60
RNA	inhibits	gene	0.60
TGFB1	associated_with	gene	0.60
TGFBR2	associated_with	gene	0.60
GATA3	regulates	gene	0.60
NRG1	inhibits	gene	0.60
RET	inhibits	gene	0.60
ERBB2	associated_with	gene	0.60
GENES	inhibits	gene	0.60
ERK	activates	gene	0.60
GAIN	activates	gene	0.60
PHGDH	activates	gene	0.60
ACAT1	activates	gene	0.60
PI3K	activates	gene	0.60
ERBB2	activates	gene	0.60
AKT	activates	gene	0.60
ACAT1	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
ELF3	therapeutic_target	gene	0.60
ERBB4	associated_with	gene	0.60
CANCER	regulates	gene	0.60
TCR	therapeutic_target	gene	0.60
AND	associated_with	gene	0.60
MAPK	activates	gene	0.60
RAS	activates	gene	0.60
MEIS1	activates	gene	0.60
CANCER	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
BACE1	therapeutic_target	gene	0.60
ST6GAL1	regulates	gene	0.60
APP	therapeutic_target	gene	0.60
MAX	regulates	gene	0.60
EGFR	therapeutic_target	gene	0.60
FUT8	regulates	gene	0.60
EGFR	associated_with	gene	0.60
APP	contributes_to	gene	0.60
Tgf-Β	associated_with	pathway	0.50
disease	associated_with	disease	0.50
BACE1	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ERBB3 in their description or question text

No additional research found