concept

ERBB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ERBB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

459Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ERBB2 is a concept in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with Als, Atherosclerosis, Cancer. Connected to 238 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ERBB2
Key Genes/Proteins	ABCA1, ABCB1, ACAT1, Actin, AKT, AKT1
Related Diseases	Als, ALS, Alzheimer
Related Pathways	Akt, Amyloid

Pathway Diagram

graph TD
    ERBB2["ERBB2"]
    ERBB2 -->|"activates"| Cancer["Cancer"]
    ERBB2 -->|"activates"| Tumor["Tumor"]
    ERBB2 -->|"activates"| Ms["Ms"]
    ERBB2 -->|"target for"| Inflammation["Inflammation"]
    ERBB2 -->|"target for"| Als["Als"]
    ERBB2 -->|"interacts"| Atherosclerosis["Atherosclerosis"]
    ERK["ERK"] -->|"activates"| ERBB2
    GAIN["GAIN"] -->|"activates"| ERBB2
    PHGDH["PHGDH"] -->|"activates"| ERBB2
    ACAT1["ACAT1"] -->|"activates"| ERBB2
    PI3K["PI3K"] -->|"activates"| ERBB2
    AKT["AKT"] -->|"activates"| ERBB2
    ELF3["ELF3"] -->|"target for"| ERBB2
    TFEB["TFEB"] -->|"activates"| ERBB2
    TFE3["TFE3"] -->|"activates"| ERBB2

Outgoing (292)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ERBB2	data_in	dataset_row	0.00
Gastric Cancer	associated_with	disease	0.98
Breast Cancer	associated_with	disease	0.98
Cell Differentiation	regulates	process	0.95
Cell Proliferation	regulates	process	0.95
Cell Survival	regulates	process	0.95
Gallbladder Cancer	associated_with	disease	0.95
Trastuzumab Deruxtecan	targets	drug	0.95
Her2 Signaling Pathway	involved_in	pathway	0.93
Her2-Low Status	associated_with	biomarker	0.90
ErbB3	interacts_with	gene	0.90
ERBB3	interacts_with	protein	0.90
Metastatic Colorectal Cancer	expressed_in	disease	0.88
Immunohistochemistry Expression	involved_in	process	0.85
Triple-Negative Breast Cancer	biomarker_for	disease	0.85
Metastatic Breast Cancer	biomarker_for	disease	0.85
ovarian cancer	biomarker_for	disease	0.85
Cancer	therapeutic_target	disease	0.85
Tumor	therapeutic_target	disease	0.85
Als	therapeutic_target	disease	0.85
Cell Proliferation	activates	process	0.85
Gallbladder Cancer	biomarker_for	disease	0.85
RAS/MAPK/ERK Signaling	downregulates	pathway	0.80
PI3K/AKT Signaling	downregulates	pathway	0.80
PI3K/AKT Signaling	modulates	pathway	0.80
RAS/MAPK/ERK Signaling	modulates	pathway	0.80
Als	activates	disease	0.75
Cancer	regulates	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Cancer	activates	disease	0.75
Als	associated_with	disease	0.75
CANCER	activates	gene	0.70
Mapk	therapeutic_target	pathway	0.70
RAS	activates	gene	0.70
Autophagy	activates	pathway	0.70
AUTOPHAGY	activates	gene	0.70
Mapk	regulates	pathway	0.70
CANCER	therapeutic_target	gene	0.70
Als	interacts_with	disease	0.65
Als	expressed_in	disease	0.65
Als	regulates	disease	0.65
Obesity	regulates	disease	0.65
Ms	interacts_with	disease	0.65
Ms	biomarker_for	disease	0.65
Cancer	biomarker_for	disease	0.65
Ms	expressed_in	disease	0.65
Tumor	interacts_with	disease	0.65
Ms	regulates	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65

Incoming (167)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ERBB2	data_in	dataset_row	0.00
EGFR	activates	gene	0.80
PI3K	therapeutic_target	gene	0.70
MMP9	therapeutic_target	gene	0.70
AKT1	therapeutic_target	gene	0.70
PI3K	activates	gene	0.70
PI3K	regulates	gene	0.70
gain_of_function	associated_with	phenotype	0.64
ERBB3	associated_with	gene	0.60
ELF3	activates	gene	0.60
TP53	activates	gene	0.60
ERBB3	activates	gene	0.60
RAS	activates	gene	0.60
NRG1	inhibits	gene	0.60
GENES	inhibits	gene	0.60
FGFR3	therapeutic_target	gene	0.60
GPX4	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
AND	inhibits	gene	0.60
NRF2	inhibits	gene	0.60
VDAC1	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
EGFR	contributes_to	gene	0.60
RAS	biomarker_for	gene	0.60
DNA	biomarker_for	gene	0.60
GENES	regulates	gene	0.60
CNR1	regulates	gene	0.60
RAS	regulates	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
CANCER	biomarker_for	gene	0.60
HER2	inhibits	gene	0.60
EGFR	inhibits	gene	0.60
CREB	activates	gene	0.60
MYC	activates	gene	0.60
AKT	regulates	gene	0.60
AKT1	regulates	gene	0.60
CANCER	regulates	gene	0.60
ERK1	regulates	gene	0.60
HER2	associated_with	gene	0.60
PIK3CA	biomarker_for	gene	0.60
CX3CR1	regulates	gene	0.60
NGF	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
GAIN	regulates	gene	0.60
RNA	regulates	gene	0.60
APOE	regulates	gene	0.60
P2RY12	regulates	gene	0.60
ERK	regulates	gene	0.60
EGFR	regulates	gene	0.60
MET	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ERBB2 in their description or question text

No additional research found