gene

E2F7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about E2F7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

0Analyses

34Outgoing

7Incoming

0Experiments

0Debates

Summary

E2F transcription factor 7 - atypical E2F functioning as transcriptional repressor

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🧬 Gene Info

Gene Symbol	E2F7
Aliases	E2F transcription factor 7
Chromosome	12q21.2
Protein Type	Transcription Factor
Function	encodes an atypical E2F transcription factor that functions primarily as a transcriptional repressor.
Molecular Weight	90 kDa
Amino Acids	816 aa
Pathways	Cell Cycle
GeneCards	E2F7
Human Protein Atlas	E2F7
Brain	High expression in developing and adult neurons, particularly in the cortex and hippocampus
Proliferating cells	Elevated in actively dividing cells
Germline tissues	Moderate expression in testis and ovary
Mature organs	Lower expression in most adult tissues with notable exceptions
Associated Diseases	neurodegeneration
Interactions	AND, CANCER, E2F1, E2F2, E2F3, E2F8
KG Connections	41 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

E2F7 Gene

gene · 2588 words

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Pathway Diagram

graph TD
    E2F7["E2F7"]
    Ms{"Ms"}
    E2F7 -->|"activates"| Ms
    Als{"Als"}
    E2F7 -->|"regulates"| Als
    ALS{"ALS"}
    E2F7 -->|"regulates"| ALS
    E2F8["E2F8"]
    E2F7 -->|"activates"| E2F8
    E2F1["E2F1"]
    E2F7 -->|"activates"| E2F1
    E2F2["E2F2"]
    E2F7 -->|"activates"| E2F2
    E2F3["E2F3"]
    E2F7 -->|"activates"| E2F3
    DNA["DNA"]
    E2F7 -->|"regulates"| DNA
    Cell_Cycle(["Cell Cycle"])
    E2F7 -->|"regulates"| Cell_Cycle
    T_Cell["T Cell"]
    E2F7 -->|"expressed in"| T_Cell
    neurodegeneration["neurodegeneration"]
    E2F7 -->|"implicated in"| neurodegeneration
    E2F8 -->|"activates"| E2F7
    E2F1 -->|"activates"| E2F7
    E2F2 -->|"activates"| E2F7
    E2F3 -->|"activates"| E2F7
    DNA -->|"regulates"| E2F7
    AND["AND"]
    AND -->|"activates"| E2F7
    style E2F7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (34)

Target	Relation	Type	Str
endocycle	inhibits	process	0.90
genome ploidy	downregulates	phenotype	0.85
Cancer	activates	disease	0.65
Als	regulates	disease	0.65
ALS	regulates	disease	0.65
Tumor	contributes_to	disease	0.65
Ms	activates	disease	0.65
Als	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
E2F3	activates	gene	0.60
AND	contributes_to	gene	0.60
GENES	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
YAP	contributes_to	gene	0.60
HDAC	contributes_to	gene	0.60
RB1	interacts_with	gene	0.60
AND	activates	gene	0.60
Hepatocyte	regulates	cell_type	0.60
Cytokine	regulates	protein	0.60
YAP	activates	gene	0.60
HDAC	inhibits	gene	0.60
YAP	inhibits	gene	0.60
E2F8	activates	gene	0.60
E2F1	activates	gene	0.60
E2F2	activates	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
Nk Cell	activates	cell_type	0.60
RB1	activates	gene	0.60
DNA	regulates	gene	0.60
T Cell	regulates	cell_type	0.60
Cell Cycle	regulates	pathway	0.60
Macrophage	expressed_in	cell_type	0.60
Ras	activates	protein	0.60
T Cell	expressed_in	cell_type	0.55

Incoming (7)

Source	Relation	Type	Str
E2F8	activates	gene	0.60
E2F1	activates	gene	0.60
E2F2	activates	gene	0.60
E2F3	activates	gene	0.60
RAD18	expressed_in	gene	0.60
TP53	inhibits	gene	0.60
DNA	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning E2F7 in their description or question text

No additional research found