gene 725 words KG: E2F1
Contents

E2F1 Gene

🧬 Gene Info
Gene SymbolE2F1
Chromosome20q11.22
Protein TypeTranscription Factor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionproliferating neural precursors - Differentiated neurons: Low expression - Glia: Variable expression - Developmental: High during neurogen
Molecular Weight47 kDa
Exons9 coding exons
PathwaysApoptosis, Autophagy, Cell Cycle
Ensembl IDENSG00000101412
GeneCardsE2F1
Human Protein AtlasE2F1
LocationChromosome 20q11.22
Gene Length~11 kb
Alternative SplicingMultiple isoforms
Associated Diseasescerebral_ischemia-reperfusion_injury
InteractionsAKT, AND, APOPTOSIS, App, APP, APP/PS1
KG Connections123 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Axonal RNA Transport Reconstitution
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

E2F regulation of endocycles in hepatocytes
validation · proposed · Score: 0.85
E2F regulation of endocycles in trophoblast giant cells
validation · proposed · Score: 0.85
E2F coordination of G2/M transcriptional program
exploratory · proposed · Score: 0.75

See Also (10)

Apoptosis in Neurodegeneration
entity · KG edge: activates
BACE1 (Redirect)
redirect · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: regulates
AIF Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

E2F7 activates E2F1
E2F8 activates E2F1
E2F1 activates E2F2
E2F1 activates E2F3
E2F1 activates RAB37
E2F1 activates E2F7
E2F1 activates HMGB1
E2F1 activates E2F8
E2F1 associated_with BECN1
E2F1 activates PI3K

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