| Gene Symbol | DMT1 |
| Aliases | SLC11A2, Divalent Metal Transporter 1 |
| Chromosome | 12q14.2 |
| Protein Type | Transporter |
| Function | DMT1 is the primary transporter for non-heme iron uptake |
| Subcellular Localization | Plasma membrane, Endosomes, Lysosomes |
| Molecular Weight | 54 kDa |
| Amino Acids | 495 aa |
| Pathways | Ferroptosis, Inflammasome, Nf-Κb, Oxidative Stress, Synaptic Plasticity |
| UniProt ID | [P49281](https://www.uniprot.org/uniprot/P49281) |
| GeneCards | DMT1 |
| Human Protein Atlas | DMT1 |
| N-terminal extracellular/domain | Contains glycosylation sites important for protein folding and trafficking |
| Transmembrane domain | Forms the ion channel pore, with conserved residues critical for metal binding and transport |
| Transport mechanism | Operates as a proton-coupled symporter, using the proton gradient to drive iron import against concentration gradients |
| Associated Diseases | Parkinson's disease |
| Known Drugs/Compounds | Dietary iron, Dietary Iron |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APP, ATF4, AUTOPHAGY |
| KG Connections | 140 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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