gene 1,339 words KG: DMT1
Contents

DMT1 Gene

🧬 Gene Info
Gene SymbolDMT1
Full NameDivalent Metal Transporter 1 (SLC11A2)
AliasesSLC11A2, Divalent Metal Transporter 1
Chromosome12q14.2
Protein TypeTransporter
FunctionDMT1 is the primary transporter for non-heme iron uptake
Subcellular LocalizationPlasma membrane, Endosomes, Lysosomes
Molecular Weight54 kDa
Amino Acids495 aa
PathwaysFerroptosis, Inflammasome, Nf-Κb, Oxidative Stress, Synaptic Plasticity
UniProt ID[P49281](https://www.uniprot.org/uniprot/P49281)
GeneCardsDMT1
Human Protein AtlasDMT1
Associated DiseasesParkinson's disease
Known Drugs/CompoundsDietary iron, Dietary Iron
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APP, ATF4, AUTOPHAGY
KG Connections142 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Metal Ion Homeostasis Dysregulation in Alzheimer's Disease
validation · proposed · Score: 0.40

See Also (9)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibits
ATF4 Gene
gene · KG edge: activates
BECN1 Gene
gene · KG edge: inhibits
CYBB — Cytochrome b-245, Beta Polypeptide
gene · KG edge: activates

Knowledge Graph (12 edges)

TFR1 associated_with DMT1
TFR1 activates DMT1
DMT1 activates GPX4
DMT1 associated_with TFR1
NCOA4 contributes_to DMT1
P62 activates DMT1
DMT1 activates KEAP1
DMT1 activates NRF2
FERROPORTIN transports DMT1
TFR1 transports DMT1

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