gene 644 words KG: DAB1
Contents

DAB1 Gene

🧬 Gene Info
Gene SymbolDAB1
Full NameDisabled-1
Chromosome1p32-p31
Protein FamilyDisabled family
Protein TypeAdaptor Protein
Functionis a key intracellular adaptor protein in the Reelin signaling pathway.
Subcellular LocalizationCytoplasm, postsynaptic densities
Molecular Weight80 kDa
Amino Acids625 aa
PathwaysDendritic Spine, Synaptic Plasticity
UniProt IDD3DX7A
NCBI Gene ID1600
Ensembl IDENSG00000170522
OMIM603448
GeneCardsDAB1
Human Protein AtlasDAB1
Associated DiseasesAls, Alzheimer, Autism, Bipolar, Depression
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOE3, APOER2
KG Connections141 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (15)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76

Related Analyses (8)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (1)

Reelin pathway defects in human type 2 lissencephaly
exploratory · proposed · Score: 0.70

See Also (6)

blarcamesine-axon
clinical_trial · KG edge: causes
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
CDK5 Gene
gene · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: regulates
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

DCX interacts_with DAB1
CDK5 interacts_with DAB1
LIS1 interacts_with DAB1
DAB1 interacts_with PAFAH1B1
JUN regulates DAB1
DAB1 associated_with FYN
DCX causes DAB1
DYNEIN causes DAB1
PAFAH1B1 causes DAB1
PAFAH1B1 interacts_with DAB1

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