protein 1,195 words KG: DAB1PROTEIN
Contents

DAB1 Protein

🔬 Protein Info
Gene SymbolDAB1
Full NameDisabled-1
Chromosome1p32-p31
Protein FamilyDisabled family
Protein TypeAdaptor Protein
Functionis a key intracellular adaptor protein in the Reelin signaling pathway.
Subcellular LocalizationCytoplasm, postsynaptic densities
Molecular Weight80 kDa
Amino Acids625 aa
PathwaysDendritic Spine, Synaptic Plasticity
UniProt IDD3DX7A
NCBI Gene ID1600
Ensembl IDENSG00000170522
OMIM603448
GeneCardsDAB1
Human Protein AtlasDAB1
Associated DiseasesAls, Alzheimer, Autism, Bipolar, Depression
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOE3, APOER2
KG Connections141 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Related Hypotheses (16)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60

Related Analyses (9)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (1)

Reelin pathway defects in human type 2 lissencephaly
exploratory · proposed · Score: 0.70

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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