concept

CELL PROLIFERATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CELL PROLIFERATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

439Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CELL PROLIFERATION
Key Genes/Proteins	ACVR2A, AKT, ALZHEIMER, AMPK, AQP4, AQUAPORIN-4
Related Diseases	acetylcholine, Alzheimer'S Disease, ALZHEIMER'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Cell Proliferation

biological_process · 1574 words

→

Pathway Diagram

graph TD
    CELL_PROLIFERATION["CELL PROLIFERATION"]
    style CELL_PROLIFERATION fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    Luteolin["Luteolin"] -.->|"inhibits"| CELL_PROLIFERATION
    MTOR([MTOR]) -->|"regulates"| CELL_PROLIFERATION
    PI3K_AKT_mTOR["PI3K/AKT/mTOR"] -->|"regulates"| CELL_PROLIFERATION
    Shikonin["Shikonin"] -.->|"inhibits"| CELL_PROLIFERATION
    HER2([HER2]) -->|"regulates"| CELL_PROLIFERATION
    FGFR["FGFR"] -->|"regulates"| CELL_PROLIFERATION
    PI3K_AKT_MTOR["PI3K/AKT/MTOR"] -->|"regulates"| CELL_PROLIFERATION

Outgoing (143)

Target	Relation	Type	Str
Wound Healing	contributes_to	process	0.95
Esophageal Squamous Cell Carcinoma	contributes_to	disease	0.90
METASTASIS	activates	process	0.80
MTOR	activates	gene	0.80
Esophageal Squamous Cell Carcinoma	promotes	disease	0.80
CHEMORESISTANCE	inhibits	phenotype	0.65
CELL DEATH	inhibits	phenotype	0.65
PI3K	activates	gene	0.65
APOPTOSIS	treats	phenotype	0.65
INFLAMMATION	implicated_in	process	0.50
HEPATOCELLULAR CARCINOMA	activates	disease	0.50
NF-KB	regulates	gene	0.50
MTOR SIGNALING	activates	process	0.50
IL-17	associated_with	concept	0.50
EGFR	activates	gene	0.50
INFLAMMATION	activates	process	0.50
ENDOTHELIAL CELLS	activates	cell_type	0.50
NEURON	regulates	cell_type	0.50
NEURON	activates	cell_type	0.50
PI3K/AKT PATHWAY	activates	concept	0.50
SLC7A11	activates	gene	0.50
FERROPTOSIS	activates	process	0.50
SRPK1	regulates	concept	0.50
SRPK1	expressed_in	concept	0.50
RAPAMYCIN	regulates	drug	0.50
CENTRAL NERVOUS SYSTEM	activates	concept	0.50
EXTRACELLULAR MATRIX	associated_with	concept	0.50
HER2	associated_with	concept	0.50
HER2	activates	concept	0.50
CELL MIGRATION	associated_with	concept	0.50
RAPAMYCIN	associated_with	concept	0.50
SGMS1	associated_with	concept	0.50
SGMS1	regulates	concept	0.50
RIBOSOME	associated_with	organelle	0.45
MTOR PATHWAY	associated_with	pathway	0.45
PI3K/AKT/MTOR	associated_with	pathway	0.45
CURCUMIN	associated_with	drug	0.45
WNT SIGNALING	associated_with	pathway	0.45
LUTEOLIN	associated_with	drug	0.45
MICROGLIA	activates	cell_type	0.45
BAICALEIN	associated_with	drug	0.45
IL6	activates	gene	0.45
PI3K/AKT PATHWAY	associated_with	pathway	0.45
MTOR SIGNALING	associated_with	pathway	0.45
FGF2	co_discussed	gene	0.40
MTOR	co_discussed	gene	0.40
PI3K	co_discussed	gene	0.40
SENESCENCE	co_discussed	process	0.40
PARP1	co_discussed	gene	0.40
ENDOTHELIAL CELLS	co_discussed	cell_type	0.40

Incoming (296)

Source	Relation	Type	Str
MTOR	regulates	protein	0.95
MTOR	promotes	gene	0.95
MTOR	regulates	entity	0.95
APOPTOSIS	regulates	process	0.95
HER2	promotes	protein	0.95
ERBB2	regulates	gene	0.95
APOPTOSIS	activates	process	0.95
CANCER	activates	disease	0.95
RAS	regulates	protein	0.95
PI3K/AKT/mTOR	regulates	pathway	0.95
mTOR	regulates	protein	0.95
Baicalein	suppresses	compound	0.95
Shikonin	inhibits	compound	0.95
Luteolin	inhibits	compound	0.95
MTOR	promotes	gene	0.95
HER2	regulates	protein	0.95
ABLIM1	promotes	protein	0.93
PI3K/AKT/MTOR	regulates	pathway	0.93
IGF2BP2	associated_with	gene	0.90
MTORC2	mediates	protein	0.90
PI3K/AKT/mTOR	regulates	pathway	0.90
Senescence	inhibits	process	0.90
ERK	promotes	pathway	0.90
ERK	regulates	protein	0.90
PI3K/AKT Signaling Pathway	activates	pathway	0.90
Gamitrinib	inhibits	drug	0.90
NPC1	inhibits	gene	0.90
SNCA	contributes_to	protein	0.90
Aloperine	inhibits	compound	0.90
USP36	upregulates	protein	0.90
MYC	promotes	gene	0.90
JUN	inhibits	gene	0.90
Hippo pathway	regulates	pathway	0.90
USP36	promotes	enzyme	0.90
PRDM4	inhibits	gene	0.90
TRIM34	promotes	gene	0.90
AP-1	regulates	protein	0.90
PRMT1	regulates	entity	0.90
PI3K/AKT	promotes	pathway	0.90
PI3K/AKT/mTOR	contributes_to	pathway	0.90
Pi3K/Akt/Mtor	promotes	pathway	0.90
TP53	regulates	gene	0.90
PTEN	inhibits	gene	0.90
NPM	regulates	protein	0.90
PI3K-AKT-mTOR	activates	pathway	0.90
Cinobufagin	inhibits	compound	0.90
EGFR	regulates	gene	0.90
Chrysotoxine	inhibits	compound	0.90
Jak/Stat	mediates	pathway	0.90
HSPA1A	regulates	gene	0.88

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CELL PROLIFERATION in their description or question text

No additional research found